CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020775
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial 
Protein Synonyms/Alias
 Cob(I)alamin adenosyltransferase; Methylmalonic aciduria type B homolog 
Gene Name
 Mmab 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
153ELERWIDKYSSQLPPacetylation[1, 2]
205ETDANVAKFLNRLSDacetylation[3]
230MKEGSQEKIYKKHDVacetylation[3]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
 NP_BIND 54 57 ATP (By similarity).
 NP_BIND 62 63 ATP (By similarity).
 NP_BIND 184 188 ATP (By similarity).
 BINDING 72 72 ATP (By similarity).
 BINDING 208 208 ATP (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MAVWLFGGRL GLRGRLSACR LLCPRFQSRG PQGGEDGDRL QPSSTAAKIP KIYTKTGDKG 60
FSSTFTGERR PKDDQVFEAV GTTDELSSAI GFAMELVTEK GHMFAEELQK IQCMLQDVGS 120
ALATPRSSAR EAHLKHTAFQ EGPVLELERW IDKYSSQLPP LKAFILPSGG KSSSALHFCR 180
AVCRRAERRV VPLVQMGETD ANVAKFLNRL SDYLFTVARY AAMKEGSQEK IYKKHDV 237 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008817; F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity; IEA:EC.
 GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR016030; AdoCbl_synth_CblAdoTrfase-like. 
Pfam
 PF01923; Cob_adeno_trans 
SMART
  
PROSITE
  
PRINTS