CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent calcium channel subunit alpha-2/delta-2 
Protein Synonyms/Alias
  
Gene Name
 CACNA2D2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
413RVQDVFEKYNWPNRTubiquitination[1]
478RPMVLAGKEAKQVQWubiquitination[1]
611KQIRTLVKSLDERYIubiquitination[1]
686IAPREYCKDLNASDNubiquitination[1]
699DNNTEFLKNFIELMEubiquitination[1]
707NFIELMEKVTPDSKQubiquitination[1]
766ITRVFPNKAAEDWTEubiquitination[1]
847DLEAWAEKFKVLASNubiquitination[1, 2]
929NNSFYTRKESYDYQAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1144 AA 
Protein Sequence
MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 60
AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 120
GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 180
GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 240
QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 300
SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 360
QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 420
VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 480
KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 540
YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 600
KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 660
KYFEFLLPSS FESEGHVFIA PREYCKDLNA SDNNTEFLKN FIELMEKVTP DSKQCNNFLL 720
HNLILDTGIT QQLVERVWRD QDLNTYSLLA VFAATDGGIT RVFPNKAAED WTENPEPFNA 780
SFYRRSLDNH GYVFKPPHQD ALLRPLELEN DTVGILVSTA VELSLGRRTL RPAVVGVKLD 840
LEAWAEKFKV LASNRTHQDQ PQKQCGPNSH CEMDCEVNNE DLLCVLIDDG GFLVLSNQNH 900
QWDQVGRFFS EVDANLMLAL YNNSFYTRKE SYDYQAACAP QPPGNLGAAP RGVFVPTVAD 960
FLNLAWWTSA AAWSLFQQLL YGLIYHSWFQ ADPAEAEGSP ETRESSCVMK QTQYYFGSVN 1020
ASYNAIIDCG NCSRLFHAQR LTNTNLLFVV AEKPLCSQCE AGRLLQKETH SDGPEQCELV 1080
QRPRYRRGPH ICFDYNATED TSDCGRGASF PPSLGVLVSL QLLLLLGLPP RPQPQVLVHA 1140
SRRL 1144 
Gene Ontology
  
Interpro
 IPR004010; Cache_domain.
 IPR013680; VDCC_a2/dsu.
 IPR013608; VWA_N.
 IPR002035; VWF_A. 
Pfam
 PF02743; Cache_1
 PF08473; VGCC_alpha2
 PF00092; VWA
 PF08399; VWA_N 
SMART
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS