| Tag | Content |
|---|
| CPLM ID | CPLM-019201 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF31 |
Protein Synonyms/Alias | HOIL-1-interacting protein; HOIP; RING finger protein 31; Zinc in-between-RING-finger ubiquitin-associated domain protein |
Gene Name | RNF31 |
Gene Synonyms/Alias | ZIBRA |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 179 | CDRPRGCKGLGLGTE | ubiquitination | [1] | | 428 | CVRTRRRKVQELQSL | ubiquitination | [1] | | 489 | PSWDGPDKQSLVRRL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. |
Sequence Annotation | DOMAIN 564 615 UBA.
ZN_FING 299 329 RanBP2-type 1.
ZN_FING 350 379 RanBP2-type 2.
ZN_FING 409 438 RanBP2-type 3.
ZN_FING 699 747 RING-type 1; degenerate.
ZN_FING 779 841 IBR-type.
ZN_FING 860 909 RING-type 2.
REGION 1 485 Polyubiquitin-binding.
REGION 563 616 Interaction with RBCK1.
REGION 910 1072 LDD domain.
MOD_RES 466 466 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Ligase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1072 AA |
Protein Sequence | MDLCTRAGEP SLTQNTHPRQ QALEQLLEDK VEDDMLQLSE FDPLLREIAP GPLTTPSVPG 60
STPGPCFLCG SAPGTLHCPS CKQALCPACD HLFHGHPSRA HHLRQTLPGV LQGTHLSPSL 120
PASAQPRPQS TSLLALGDSS LSSPNPASAH LPWHCAACAM LNEPWAVLCV ACDRPRGCKG 180
LGLGTEGPQG TGGLEPDLAR GRWACQSCTF ENEAAAVLCS ICERPRLAQP PSLVVDSRDA 240
GICLQPLQQG DALLASAQSQ VWYCIHCTFC NSSPGWVCVM CNRTSSPIPA QHAPRPYASS 300
LEKGPPKPGP PRRLSAPLPS SCGDPEKQRQ DKMREEGLQL VSMIREGEAA GACPEEIFSA 360
LQYSGTEVPL QWLRSELPYV LEMVAELAGQ QDPGLGAFSC QEARRAWLDR HGNLDEAVEE 420
CVRTRRRKVQ ELQSLGFGPE EGSLQALFQH GGDVSRALTE LQRQRLEPFR QRLWDSGPEP 480
TPSWDGPDKQ SLVRRLLAVY ALPSWGRAEL ALSLLQETPR NYELGDVVEA VRHSQDRAFL 540
RRLLAQECAV CGWALPHNRM QALTSCECTI CPDCFRQHFT IALKEKHITD MVCPACGRPD 600
LTDDTQLLSY FSTLDIQLRE SLEPDAYALF HKKLTEGVLM RDPKFLWCAQ CSFGFIYERE 660
QLEATCPQCH QTFCVRCKRQ WEEQHRGRSC EDFQNWKRMN DPEYQAQGLA MYLQENGIDC 720
PKCKFSYALA RGGCMHFHCT QCRHQFCSGC YNAFYAKNKC PEPNCRVKKS LHGHHPRDCL 780
FYLRDWTALR LQKLLQDNNV MFNTEPPAGA RAVPGGGCRV IEQKEVPNGL RDEACGKETP 840
AGYAGLCQAH YKEYLVSLIN AHSLDPATLY EVEELETATE RYLHVRPQPL AGEDPPAYQA 900
RLLQKLTEEV PLGQSIPRRR K 921 |
Gene Ontology | GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL. GO:0071797; C:LUBAC complex; IDA:UniProtKB. GO:0043130; F:ubiquitin binding; IDA:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0023035; P:CD40 signaling pathway; ISS:BHF-UCL. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB. GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB. GO:0097039; P:protein linear polyubiquitination; IDA:UniProtKB. GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB. |
Interpro | |
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SMART | |
PROSITE | |
PRINTS | |