CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase HECTD1 
Protein Synonyms/Alias
  
Gene Name
 HECTD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
421VERINVFKTAFSENEubiquitination[1, 2, 3]
515YLLKMVAKQWYDFDRubiquitination[2]
746LVRSQVLKYMVPGARubiquitination[4, 5]
761VIRGLDWKWRDQDGSubiquitination[2, 4, 5]
798VKNNCPDKTSAAAGSubiquitination[2]
809AAGSSSRKGSSSSVCubiquitination[2]
890GSENAERKLGPDSSVubiquitination[2]
927SVSELTNKEAASQRPubiquitination[1, 3, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1465 AA 
Protein Sequence
VFAQTFQQTM LPSIRKASLA LIRKMIHFCS EALLKEVCDS DVGHNLPTIL VEITATVLDQ 60
EDDDDGHLLA LQIIRDLVDK GGDIFLDQLA RLGVISKVST LAGPSSDDEN EEESKPEKED 120
EPQEDAKELQ QGKPYHWRDW SIIRGRDCLY IWSDAAALEL SNGSNGWFRF ILDGKLATMY 180
SSGSPEGGSD SSESRSEFLE KLQRARGQVK PSTSSQPILS APGPTKLTVG NWSLTCLKEG 240
EIAIHNSDGQ QATILKEDLP GFVFESNRGT KHSFTAETSL GSEFVTGWTG KRGRKLKSKL 300
EKTKQKVRTM ARDLYDDHFK AVESMPRGVV VTLRNIATQL ESSWELHTNR QCIESENTWR 360
DLMKTALENL IVLLKDENTI SPYEMCSSGL VQALLTVLNN SMDLDMKQDC SQLVERINVF 420
KTAFSENEDD ESRPAVALIR KLIAVLESIE RLPLHLYDTP GSTYNLQILT RRLRFRLERA 480
PGETALIDRT GRMLKMEPLA TVESLEQYLL KMVAKQWYDF DRSSFVFVRK LREGQNFIFR 540
HQHDFDENGI IYWIGTNAKT AYEWVNPAAY GLVVVTSSEG RNLPYGRLED ILSRDNSALN 600
CHSNDDKNAW FAIDLGLWVI PSAYTLRHAR GYGRSALRNW VFQVSKDGQN WTSLYTHVDD 660
CSLNEPGSTA TWPLDPPKDE KQGWRHVRIK QMGKNASGQT HYLSLSGFEL YGTVNGVCED 720
QLGKAAKEAE ANLRRQRRLV RSQVLKYMVP GARVIRGLDW KWRDQDGSPQ GEGTVTGELH 780
NGTTQSWSSL VKNNCPDKTS AAAGSSSRKG SSSSVCSVAS SSDISLGSTK TERRSEIVME 840
HSIVSGADVH EPIVVLSSAE NVPQTEVGSS SSASTSTLTA ETGSENAERK LGPDSSVRTP 900
GESSAISMGI VSVSSPDVSS VSELTNKEAA SQRPLSSSAS NRLSVSSLLA AGAPMSSSAS 960
VPNLSSRETS SLESFVRRVA NIARTNATNN MNLSRSSSDN NTNTLGRNVM STATSPLMGA 1020
QSFPNLTTPG TTSTVTMSTS SVTSSSNVAT ATTVLSVGQS LSNTLTTSLT STSSESDTGQ 1080
EAEYSLYDFL DSCRASTLLA ELDDDEDLPE PDEEDDENED DNQEDQEYEE VMILRRPSLQ 1140
RRAGSRSDVT HHAVTSQLPQ VPAGAGSRPI GEQEEEEYET KGGRRRTWDD DYVLKRQFSA 1200
LVPAFDPRPG RTNVQQTTDL EIPPPGTPHS ELLEEVECTP SPRLALTLKV TGLGTTREVE 1260
LPLTNFRSTI FYYVQKLLQL SCNGNVKSDK LRRIWEPTYT IMYREMKDSD KEKENGKMGC 1320
WSIEHVEQYL GTDELPKNDL ITYLQKNADA AFLRHWKLTG TNKSIRKNRN CSQLIAAYKD 1380
FCEHGTKSGL NQGAISTLQS SDILNLTKEQ PQAKAGNGQN SCGVEDVLQL LRILYIVASD 1440
PYSRISQEDG DEQLQFTFPP DEFTS 1465 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. 
Interpro
 IPR008979; Galactose-bd-like.
 IPR010606; Mib_Herc2.
 IPR012919; Sad1_UNC_C. 
Pfam
 PF06701; MIB_HERC2
 PF07738; Sad1_UNC 
SMART
  
PROSITE
 PS51416; MIB_HERC2 
PRINTS