CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019204
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Small glutamine-rich tetratricopeptide repeat-containing protein beta 
Protein Synonyms/Alias
 Beta-SGT; Small glutamine-rich protein with tetratricopeptide repeats 2 
Gene Name
 SGTB 
Gene Synonyms/Alias
 SGT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MSSIKHLVYAVIubiquitination[1, 2, 3, 4]
84SVPEDVGKADQLKDEubiquitination[5]
151KAIAIDSKYSKAYGRubiquitination[2, 4]
168LALTALNKFEEAVTSubiquitination[6]
178EAVTSYQKALDLDPEubiquitination[5, 6]
190DPENDSYKSNLKIAEubiquitination[4, 5, 6]
194DSYKSNLKIAEQKLRubiquitination[4, 5, 6]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity). 
Sequence Annotation
 REPEAT 15 49 TPR 1.
 REPEAT 85 118 TPR 2.
 REPEAT 119 152 TPR 3.
 REPEAT 153 186 TPR 4.
 MOD_RES 295 295 Phosphoserine.
 MOD_RES 297 297 Phosphoserine.  
Keyword
 Chaperone; Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 304 AA 
Protein Sequence
MSSIKHLVYA VIRFLREQSQ MDTYTSDEQE SLEVAIQCLE TVFKISPEDT HLAVSQPLTE 60
MFTSSFCKND VLPLSNSVPE DVGKADQLKD EGNNHMKEEN YAAAVDCYTQ AIELDPNNAV 120
YYCNRAAAQS KLGHYTDAIK DCEKAIAIDS KYSKAYGRMG LALTALNKFE EAVTSYQKAL 180
DLDPENDSYK SNLKIAEQKL REVSSPTGTG LSFDMASLIN NPAFISMAAS LMQNPQVQQL 240
MSGMMTNAIG GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA 300
EEHS 304 
Gene Ontology
  
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS