UniProt Accession

 ACMSD_MOUSE; Q8R519; B9EI97; Q3UNW3 

Genbank Protein ID

 AK143962; BC139281; AB071419 

Genbank Nucleotide ID

 BAE25634.1; AAI39282.1; BAB86939.1 

Protein Name

 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase 

Protein Synonyms/Alias

 Picolinate carboxylase 

Gene Name

 Acmsd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	KEWPDLEKRFGYGGW	ubiquitination	[1]
257	DNPSDPRKYLGSFYT	ubiquitination	[1]
283	LLTDVIGKDKVMLGT	ubiquitination	[1]
318	FDEETKDKLTAGNAL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. 

Sequence Annotation

 METAL 6 6 Zinc (By similarity).
 METAL 8 8 Zinc (By similarity).
 METAL 174 174 Zinc (By similarity).
 METAL 291 291 Zinc (By similarity).
 BINDING 47 47 Substrate (By similarity).
 MOD_RES 7 7 Phosphothreonine.
 MOD_RES 116 116 Phosphothreonine.  

Keyword

 Complete proteome; Decarboxylase; Lyase; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 336 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0001760; F:aminocarboxymuconate-semialdehyde decarboxylase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046874; P:quinolinate metabolic process; ISS:UniProtKB. 

Interpro

 IPR006992; Amidohydro_2. 

Pfam

 PF04909; Amidohydro_2 

SMART

  

PROSITE

  

PRINTS