CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018208
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisome proliferator-activated receptor gamma coactivator 1-beta 
Protein Synonyms/Alias
 PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; ERR ligand 1 
Gene Name
 Ppargc1b 
Gene Synonyms/Alias
 Errl1; Pgc1; Pgc1b; Ppargc1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
202VDGTQDKKTPTLRAQacetylation[1]
218RPCTELHKHLTSVLPacetylation[1]
230VLPCPRVKACSPTPHacetylation[1]
455EEEEWGRKRPGRGLPacetylation[1]
469PWTKLGRKMDSSVCPacetylation[1]
645ATPGASHKLPKRHPEacetylation[1]
674PVSQAGQKRPFSCSFacetylation[1]
726APLPTETKAPRREANacetylation[1]
933TRSKRGQKHGFITFRacetylation[1]
994ESLPSSGKSKYEAMDacetylation[1]
Reference
 [1] GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation.
 Kelly TJ, Lerin C, Haas W, Gygi SP, Puigserver P.
 J Biol Chem. 2009 Jul 24;284(30):19945-52. [PMID: 19491097] 
Functional Description
 Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta- oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. 
Sequence Annotation
 DOMAIN 893 967 RRM.
 REGION 1 91 Abolishes DNA transcriptional activity
 MOTIF 140 144 LXXLL motif 1.
 MOTIF 156 160 LXXLL motif 2.
 MOTIF 343 347 LXXLL motif 3.
 MOTIF 683 686 HCFC1-binding-motif (HBM).
 MOD_RES 519 519 Phosphoserine (By similarity).  
Keyword
 Activator; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1014 AA 
Protein Sequence
MAGNDCGALL DEELSSFFLN YLSDTQGGDS GEEQLCADLP ELDLSQLDAS DFDSATCFGE 60
LQWCPETSET EPSQYSPDDS ELFQIDSENE ALLAALTKTL DDIPEDDVGL AAFPELDEGD 120
TPSCTPASPA PLSAPPSPTL ERLLSPASDV DELSLLQKLL LATSSPTASS DALKDGATWS 180
QTSLSSRSQR PCVKVDGTQD KKTPTLRAQS RPCTELHKHL TSVLPCPRVK ACSPTPHPSP 240
RLLSKEEEEE VGEDCPSPWP TPASPQDSLA QDTASPDSAQ PPEEDVRAMV QLIRYMHTYC 300
LPQRKLPQRA PEPIPQACSS LSRQVQPRSR HPPKAFWTEF SILRELLAQD ILCDVSKPYR 360
LAIPVYASLT PQSRPRPPKD SQASPAHSAM AEEVRITASP KSTGPRPSLR PLRLEVKRDV 420
NKPTRQKREE DEEEEEEEEE EEEEKEEEEE EWGRKRPGRG LPWTKLGRKM DSSVCPVRRS 480
RRLNPELGPW LTFTDEPLGA LPSMCLDTET HNLEEDLGSL TDSSQGRQLP QGSQIPALES 540
PCESGCGDTD EDPSCPQPTS RDSSRCLMLA LSQSDSLGKK SFEESLTVEL CGTAGLTPPT 600
TPPYKPMEED PFKPDTKLSP GQDTAPSLPS PEALPLTATP GASHKLPKRH PERSELLSHL 660
QHATTQPVSQ AGQKRPFSCS FGDHDYCQVL RPEAALQRKV LRSWEPIGVH LEDLAQQGAP 720
LPTETKAPRR EANQNCDPTH KDSMQLRDHE IRASLTKHFG LLETALEGED LASCKSPEYD 780
TVFEDSSSSS GESSFLLEEE EEEEEGGEED DEGEDSGVSP PCSDHCPYQS PPSKASRQLC 840
SRSRSSSGSS SCSSWSPATR KNFRRESRGP CSDGTPSVRH ARKRREKAIG EGRVVYIRNL 900
SSDMSSRELK KRFEVFGEIV ECQVLTRSKR GQKHGFITFR CSEHAALSVR NGATLRKRNE 960
PSFHLSYGGL RHFRWPRYTD YDPTSEESLP SSGKSKYEAM DFDSLLKEAQ QSLH 1014 
Gene Ontology
 GO:0016592; C:mediator complex; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0050682; F:AF-2 domain binding; ISS:UniProtKB.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0030546; F:receptor activator activity; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:Compara.
 GO:0007015; P:actin filament organization; IMP:DFLAT.
 GO:0060346; P:bone trabecula formation; IMP:DFLAT.
 GO:0034614; P:cellular response to reactive oxygen species; IDA:DFLAT.
 GO:0030520; P:intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:DFLAT.
 GO:0001503; P:ossification; IMP:DFLAT.
 GO:0010694; P:positive regulation of alkaline phosphatase activity; IMP:DFLAT.
 GO:0045780; P:positive regulation of bone resorption; IMP:DFLAT.
 GO:0045672; P:positive regulation of osteoclast differentiation; IMP:DFLAT.
 GO:0042327; P:positive regulation of phosphorylation; IMP:DFLAT.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0006390; P:transcription from mitochondrial promoter; IMP:DFLAT. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS