CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015740
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptic vesicle glycoprotein 2A 
Protein Synonyms/Alias
  
Gene Name
 SV2A 
Gene Synonyms/Alias
 KIAA0736; PSEC0174 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
143RGEAQRRKEREELAQubiquitination[1]
366RFFLENGKHDEAWMVubiquitination[2, 3]
375DEAWMVLKQVHDTNMubiquitination[2, 3]
485VDYASRTKVFPGERVubiquitination[4]
515GGQYFNDKFIGLRLKubiquitination[4]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). 
Sequence Annotation
 REGION 1 57 Interaction with SYT1 (By similarity).
 MOD_RES 65 65 Phosphotyrosine (By similarity).
 MOD_RES 66 66 Phosphotyrosine (By similarity).
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 81 81 Phosphoserine.
 MOD_RES 84 84 Phosphothreonine.
 MOD_RES 127 127 Phosphoserine (By similarity).
 MOD_RES 480 480 Phosphotyrosine (By similarity).
 CARBOHYD 498 498 N-linked (GlcNAc...) (Potential).
 CARBOHYD 548 548 N-linked (GlcNAc...) (Potential).
 CARBOHYD 573 573 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 742 AA 
Protein Sequence
MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE EEDDDDDFPA 60
PSDGYYRGEG TQDEEEGGAS SDATEGHDED DEIYEGEYQG IPRAESGGKG ERMADGAPLA 120
GVRGGLSDGE GPPGGRGEAQ RRKEREELAQ QYEAILRECG HGRFQWTLYF VLGLALMADG 180
VEVFVVGFVL PSAEKDMCLS DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS 240
VNSVFAFFSS FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 300
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA LTTQPESPRF 360
FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI HQEDELIEIQ SDTGTWYQRW 420
GVRALSLGGQ VWGNFLSCFG PEYRRITLMM MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY 480
ASRTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT 540
SSNTFFRNCT FINTVFYNTD LFEYKFVNSR LINSTFLHNK EGCPLDVTGT GEGAYMVYFV 600
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA MIALLCLFGG 660
VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG ISIFTSFVGI TKAAPILFAS 720
AALALGSSLA LKLPETRGQV LQ 742 
Gene Ontology
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0048786; C:presynaptic active zone; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. 
Interpro
 IPR001646; 5peptide_repeat.
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR005829; Sugar_transporter_CS.
 IPR022308; SV2. 
Pfam
 PF07690; MFS_1
 PF13599; Pentapeptide_4
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS