CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016623
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynein heavy chain 3, axonemal 
Protein Synonyms/Alias
 Axonemal beta dynein heavy chain 3; Ciliary dynein heavy chain 3 
Gene Name
 Dnah3 
Gene Synonyms/Alias
 Dnahc3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1940TINAESRKKFDVFFRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). 
Sequence Annotation
 NP_BIND 1396 1403 ATP (Potential).
 NP_BIND 1677 1684 ATP (Potential).
 NP_BIND 2041 2048 ATP (Potential).
 NP_BIND 2401 2408 ATP (Potential).
 REGION 1 1357 Stem (By similarity).
 REGION 1358 1579 AAA 1 (By similarity).
 REGION 1639 1870 AAA 2 (By similarity).
 REGION 2003 2251 AAA 3 (By similarity).
 REGION 2362 2613 AAA 4 (By similarity).
 REGION 2628 2927 Stalk (By similarity).
 REGION 3012 3242 AAA 5 (By similarity).
 REGION 3455 3679 AAA 6 (By similarity).
 MOD_RES 3581 3581 Phosphoserine.
 MOD_RES 3584 3584 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4083 AA 
Protein Sequence
MSDTNCSAQK LDKSDSVHHM SHSQARPELP PLPVSANEEP SELYKTVMSH SFYPPLMQRT 60
SWTLAVPFKE QDHHRGPSDS IGNNYSLTAR DMKLKDLLKV YQPVTISIPR DKTSQGLPLG 120
TSSKTSTEPS KKKMKFNLKA KDDVTGMPFV CKFSSSLSIK NTTDSSVTHP ESRPMSPEQQ 180
MDVMLQQEME IESKEQKPSE LDLERYYYYL TNGIRKDMIA PENEEVMMRI YKLIPKTLLT 240
TPALEPLQVS LRSEKESDYY YSLMKSIVDY ILMDPMEKKR LFIKSIPRLF PHRVIRAPVP 300
WHNIYQSTKK WNEEHLHTVN PMMYKLKELW FAEFQNLRFV RTADLLAGKL PLLPHEYKEV 360
VQKHCREARH ILLTKWIPTC AQLFVTQKEH WVHFAPKNDY DSSRNIEEYF ASVASFMSLQ 420
LRDLVIKSLR DLVSFFMIHK DGNDFKEPYQ EMDFFIPQLI MIKLEVRDPI IVFNPTFDDC 480
WQLIKNSFLE IIKNSDGIPK VYLCWKPLAS YICVSPHLRM TSVLQVESIL FPDLKGYNMI 540
LGTVNPEESL VSDFLDQTLE VFKKNQVGPY KYLNVYKKYD DLLDNMAEKG ISEFLKEKHE 600
IEDFVTSINS IKKRKNEIAS MHITVPLAMF CLDAVFLNYD LCERAQNLKD NLILYQVDVN 660
RETNTSICNQ YSTIADKVSE IPANTAELVA LIEYLKKSSD VTVFKLRRQL RDASERLEFL 720
MDYADLPSES IEDVFESSRN LLMSKRDQAE MDLIKRCSEF ESRLEGYSKE LEMFRKREVM 780
TTEEMKNNVE KLHDLSKNLD LALTEFELIN KEEELLEKEK SSFPLLQTLM INKIPYEQLW 840
VTAYEFSTKS EEWMNGPLYL MNAEQIAEEI GNMWRTTYKL TKTLIDVPAP KRLAENVKLK 900
IEKFKQHIPI LNIACNPGMK DRHWQQISDI VGYEIKPTET TCLANMLEYG FGKFVDKLEP 960
IGAAASKEYS LEKNLEKMKA DWVNMCFSFV KYRDTDTSIL CAVDDIQLIL DDHVIKTQTM 1020
CGSVFIKPIE AECRKWEEKL VRVQENLDAW LKCQVTWLYL EPIFSSEDII AQMPEEGKKF 1080
TTVDTYWKSL MAQAVNDTRV MVAADQPRMT EKLQEANVLL EDIQRGLNDY LEKKRLFFPR 1140
FFFLSNDELL EILSETKDPL RVQPHLKKCF EGIAKLEFTD NLEIKGMISS EKETVPFIQT 1200
IYPVKAKGMV EKWLQQVEQV MLASMRQVIE NGIEAYVQVP RNAWVLEWPG QVVICVSSIF 1260
WTREVSEALV EDTLTDFLKK SNDQIAQIVE LVRGKLSSGA RLTLGALTVI DVHARDVVAK 1320
LRHDHINSLN DFQWISQLRY YWTEKNVHVQ MITTEALYGY EYLGNSPRLV ITPLTDRCYR 1380
TLMGALKLNL GGAPEGPAGT GKTETTKDLA KALAKQCVVF NCSDGLDYKA MGKFFKGLAQ 1440
AGAWACFDEF NRIEVEVLSV VAQQILSIQQ AIIRKLKRFI FEGTELSLNP TCAVFITMNP 1500
GYAGRAELPD NLKALFRTVA MMVPDYALIG EISLYSMGFL DSRSLAQKIV ATYRLCSEQL 1560
SSQHHYDYGM RAVKSVLTAA GNLKLKYPEE NESVLLLRAL LDVNLAKFLA QDVPLFQGII 1620
SDLFPGVVLP KPDYEVFLEA LNNNIRKMKL QPVPWFIGKI IQIYEMMLVR HGYMIVGDPM 1680
GGKTSAYKVL AAALGDLHAA NQMEEFAVEF KIINPKAITM GQLYGCFDAV SHEWTDGVLA 1740
NAFREQASSI TDDRKWIIFD GPVDAVWIEN MNTVLDDNKK LCLMSGEIIQ MSSKMSLIFE 1800
PADLEQASPA TVSRCGMIYM EAHQLGWKPL KDSYMDTLPR CLTKEHTELV EDMFTWLVQP 1860
CLDFSRLHCK FVVQTSPIHL AFSMMRLYSS LLDEIRDIQE EEMEIYEGLS SQQIFLWLQG 1920
LFLFSLVWTL AGTINAESRK KFDVFFRNLI MGMDDRNPRP KSVKLTKNNI FPERGSIYDF 1980
YFLKQGGGHW NAWTEYITKE EETIPANAKV SDLIIPTMET ARQSFFLKTY LDHEIPILFV 2040
GPTGTGKSAI TNDFLLHLPK NVYQPNFINF SARTSANQTQ DIIMSKLDRR RKGLFGPPIG 2100
KKAVVFVDDL NMPAKEVYGA QPPIELLRQW IDHGYWFDKK DTNRLDIVDV LLVTAMGPPG 2160
GGRNDITGRF TRHLNIISIN AFEDEILTKI FSSIADWHFG KGFDVMFLRY GKMLVQATQT 2220
IYRAAVENFL PTPSKSHYVF NLRDFSRVIQ GVLLCPHTHL QDLEKFIRLW IHEVYRVFYD 2280
RLIDNDDRQT FFNLVKETTS NCFKQTMEKV LIHLSPTGKI TDDNIRSLFF GDYLKPESDQ 2340
KIYDEIIDLR GLTVVMEYYL DEFNSVSKAP MSLVMFKFAI EHISRICRVL KQKKGHLLLV 2400
GIGGSGRQSA TKLSTFMNSY ELYQIEITKN YTNSDWREDL KKIMLQSGVA TKSTVFLFSD 2460
NQIKHESFVE DINMLLNTGD VPNIFPADEK ADLVEKMQTA ARTEGEKVEA TPLSMYNFFI 2520
ERGTNRAYFS LAMSPIGDAF RTRLRMFPSL INCCTIDWFQ SWPTDALELV ANKFLEDVEL 2580
DDNIRAEVVS MCKYFQESVK KLSVDYYNTL LRHNYVTPTS YLELILTFKT LLNSKRQEVD 2640
TIRNRYLAGL QKLEFASSQV AVMQVELTAL QPQLIQTSED TAMMMVKIEL ETKEADAKKL 2700
LVQADEKEAN AAAAISQAIK NECEGDLAEA MPALEAALAA LDTLNPSDIT LVKSMQNPPG 2760
PVKLVMESIC VMKGLKPERK PDPSGSGKMI EDYWGVSRKI LGDLKFLESL KTYDKDNIPS 2820
VIMKRIRERF IDHPDFQPAV IKNVSSACEG LCKWVRAMEV YDRVAKVVAP KRERLREAEG 2880
KLEIQMQKLN QKRAELKLVE DRLQDLNDEF ELMNRKKNSL EKNIEICSQK LVRAEKLISG 2940
LGGEKDRWTE AARQLGIRYD NLTGDVLLAS GTVAYLGAFT VDYRAQCQNE WLVSCKDKVI 3000
PGSVDFSLSN TLGDPIKIRA WQIAGLPVDS FSVDNGIIVS NSRRWPLMID PQGQANKWVK 3060
NMEKTNKLSV IKFSDTNYVR TLENALQFGT PVLLENVGEE LDAFIEPILL KATFKQQGVE 3120
YMRLGENIIE YSREFKFYIT TRLRNPHYLP EVAVKVCLLN FMITPLGLQD QLLGIVAAKE 3180
KPELEEKKNK LILESAQNKK QLKEIEDKIL EVLSLCEGNI LEDETAIKIL SSSKVLSEEI 3240
SEKQEIASVT ETQIDETRMG YKPVAVHSAA IFFCISDLAH IEPMYQYSLT WFINLYVQSL 3300
ANSNKSDELD LRIEYIIEHF TLSIYNNVCR SLFEKDKLLF SLLLTVGLLK ERKAIDEEVW 3360
YFLLTGGVAL DNPFPNPAPE WLSEKSWGEI VRASSLQKLK GLMEDVMQNI KVWKDIYDSA 3420
WPHEESLPSP WFFLQTLEKI AILRCLRPDK IVPAIQNFIC ETMGKIFIEA PTFDLQGSYG 3480
DSSCCVPLIF ILSPGADPMA GLLKFADDVS MGGTKTQTIS LGQGQGPIAA NMINKAIHEG 3540
TWVVLQNCHL ATSWMPALEK ICEEVIVPEN TNSEFRLWLT SYPSEKFPVS ILQNGIKMTN 3600
EPPKGLRANL LRSYLNDPIS DPLFFQSCTK PVIWQKLLFG LCFFHAIVQE RRNYGALGWN 3660
IPYEFNESDL RISMRQIQMF LNDYEEVPFE ALTYLTGECN YGGRVTDDKD RRLLLSLLSM 3720
FYCKEIETDN YHIAPGDAYV IPPYGSYQSY IEYLRTLPIT AHPEVFGLHE NADITKDNQE 3780
TNQLFQGVLL TLPRQSGGSG KSPQEVVEEL AQDILSKLPN DFNLEEVMKK YPVVYKESMN 3840
TVLRQELIRF NRLTKVVRRS LIDLGRAIKG QVLMSSELEE VFNSMLVGKV PAMWAAKSYP 3900
SLKPLGGYVA DLLARLTFFQ EWIDKGPPVV FWISGFYFTQ SFLTGVSQNY ARKYTIPIDH 3960
IGFEFEVTPK ETTMENIPED GAYIKGLFLE GARWDRSTSQ IGESLPKILY DPLPIIWLKP 4020
GESASFLHQD IYVCPVYKTS ARRGILSTTG HSTNYVLSIE LPTDMPQKHW INRGVASLCQ 4080
LDN 4083 
Gene Ontology
 GO:0005858; C:axonemal dynein complex; IEA:InterPro.
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0001539; P:ciliary or flagellar motility; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR026983; DHC_fam.
 IPR026977; DNAH3.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF12780; AAA_8
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS