CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004424
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin-1 
Protein Synonyms/Alias
 ANK-1; Ankyrin-R; Erythrocyte ankyrin 
Gene Name
 ANK1 
Gene Synonyms/Alias
 ANK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
59ASKEGHVKMVVELLHubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. 
Sequence Annotation
 REPEAT 44 73 ANK 1.
 REPEAT 77 106 ANK 2.
 REPEAT 110 139 ANK 3.
 REPEAT 143 172 ANK 4.
 REPEAT 174 201 ANK 5.
 REPEAT 205 234 ANK 6.
 REPEAT 238 267 ANK 7.
 REPEAT 271 300 ANK 8.
 REPEAT 304 333 ANK 9.
 REPEAT 337 366 ANK 10.
 REPEAT 370 399 ANK 11.
 REPEAT 403 432 ANK 12.
 REPEAT 436 465 ANK 13.
 REPEAT 469 498 ANK 14.
 REPEAT 502 531 ANK 15.
 REPEAT 535 564 ANK 16.
 REPEAT 568 597 ANK 17.
 REPEAT 601 630 ANK 18.
 REPEAT 634 663 ANK 19.
 REPEAT 667 696 ANK 20.
 REPEAT 700 729 ANK 21.
 REPEAT 733 762 ANK 22.
 REPEAT 766 795 ANK 23.
 DOMAIN 911 1066 ZU5 1.
 DOMAIN 1067 1233 ZU5 2.
 DOMAIN 1403 1487 Death.
 REGION 1 827 89 kDa domain.
 REGION 1234 1362 UPA domain (By similarity).
 REGION 1383 1881 55 kDa regulatory domain.
 MOD_RES 105 105 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 233 233 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 431 431 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 464 464 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 629 629 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 662 662 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 695 695 (3S)-3-hydroxyaspartate; by HIF1AN;
 MOD_RES 728 728 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 761 761 (3S)-3-hydroxyasparagine; by HIF1AN;
 MOD_RES 856 856 Phosphoserine (By similarity).
 MOD_RES 1073 1073 Phosphotyrosine (By similarity).  
Keyword
 3D-structure; Alternative promoter usage; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Elliptocytosis; Hereditary hemolytic anemia; Hydroxylation; Lipoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Sarcoplasmic reticulum. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1881 AA 
Protein Sequence
MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 60
VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 120
ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 180
ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 240
TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 300
KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 360
GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 420
KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 480
GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 540
HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 600
NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 660
GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 720
LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 780
SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 840
KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 900
NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 960
TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 1020
RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 1080
GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 1140
FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 1200
ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 1260
MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 1320
NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 1380
PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 1440
NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 1500
DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 1560
LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 1620
VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 1680
ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 1740
GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 1800
EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 1860
LEVDIDYFMK HSKDHTSTPN P 1881 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; NAS:UniProtKB.
 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031430; C:M band; IEA:UniProtKB-SubCell.
 GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0014731; C:spectrin-associated cytoskeleton; IDA:BHF-UCL.
 GO:0008093; F:cytoskeletal adaptor activity; TAS:UniProtKB.
 GO:0019899; F:enzyme binding; TAS:UniProtKB.
 GO:0030507; F:spectrin binding; NAS:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IDA:BHF-UCL.
 GO:0048821; P:erythrocyte development; IEA:Compara.
 GO:0006887; P:exocytosis; NAS:UniProtKB.
 GO:0045199; P:maintenance of epithelial cell apical/basal polarity; TAS:UniProtKB.
 GO:0015672; P:monovalent inorganic cation transport; IEA:Compara.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:Compara.
 GO:0072661; P:protein targeting to plasma membrane; IMP:BHF-UCL.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR000906; ZU5. 
Pfam
 PF00023; Ank
 PF00531; Death
 PF00791; ZU5 
SMART
 SM00248; ANK
 SM00005; DEATH
 SM00218; ZU5 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50017; DEATH_DOMAIN
 PS51145; ZU5 
PRINTS
 PR01415; ANKYRIN.