UniProt Accession

 ST1C1_RAT; P50237; Q5M8B5 

Genbank Protein ID

 L22339; BC088125 

Genbank Nucleotide ID

 AAA42181.1; AAH88125.1 

Protein Name

 Sulfotransferase 1C1 

Protein Synonyms/Alias

 ST1C1; HAST-I; N-hydroxyarylamine sulfotransferase 

Gene Name

 Sult1c1 

Gene Synonyms/Alias

 St1c1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
115	MPSPRTLKTHLPVHM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines (By similarity). 

Sequence Annotation

 NP_BIND 56 61 PAPS (By similarity).
 NP_BIND 236 241 PAPS (By similarity).
 NP_BIND 264 268 PAPS (By similarity).
 REGION 115 117 Substrate binding (By similarity).
 ACT_SITE 117 117 Proton acceptor (By similarity).
 BINDING 139 139 PAPS (By similarity).
 BINDING 147 147 PAPS (By similarity).
 BINDING 202 202 PAPS (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:RGD.
 GO:0004062; F:aryl sulfotransferase activity; IDA:RGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS