CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000707
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acidic fibroblast growth factor intracellular-binding protein 
Protein Synonyms/Alias
 aFGF intracellular-binding protein; FGF-1 intracellular-binding protein 
Gene Name
 FIBP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75RLLHAPPKLLHQLIFubiquitination[1]
118KLSKGTKKDLDDISTubiquitination[1]
126DLDDISTKTGITLKSubiquitination[1, 2]
132TKTGITLKSCRRQFDubiquitination[1]
146DNFKRVFKVVEEMRGubiquitination[1]
245LQDLKELKVLVADKDubiquitination[3, 4]
251LKVLVADKDLLDLHKubiquitination[3, 4, 5]
258KDLLDLHKSLVCTALubiquitination[1, 5]
268VCTALRGKLGVFSEMubiquitination[1, 5]
280SEMEANFKNLSRGLVubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May be involved in mitogenic function of FGF1. 
Sequence Annotation
 MOD_RES 2 2 N-acetylthreonine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Membrane; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 364 AA 
Protein Sequence
MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA VLQSDTMDHY 60
RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD EAFVREVLGK KLSKGTKKDL 120
DDISTKTGIT LKSCRRQFDN FKRVFKVVEE MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA 180
NNRFETGKKK LQYLSFGDFA FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD 240
LKELKVLVAD KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR 300
DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY MGTLRGCLLR 360
LYHD 364 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005739; C:mitochondrion; TAS:ProtInc.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:ProtInc. 
Interpro
 IPR008614; FIBP. 
Pfam
 PF05427; FIBP 
SMART
  
PROSITE
  
PRINTS