CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011836
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-terminal acetyltransferase B complex subunit MDM20 
Protein Synonyms/Alias
 NatB complex subunit MDM20; Dislikes extra CIN8 protein 1; Mitochondrial distribution and morphology protein 20 
Gene Name
 MDM20 
Gene Synonyms/Alias
 DEC1; YOL076W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
67LEEPYGLKGTTITGDubiquitination[1]
129SNYNQMSKASLQLAKubiquitination[1]
791NSLLGIQKSVRNL**acetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met- Asp or Met-Glu and of some proteins beginning with Met-Asn or Met- Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions. MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables. Genetically interacts with CIN8. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 796 AA 
Protein Sequence
MSDKIQEEIL GLVSRSNFKQ CYAKLGQLQK QFPNALYFKI LETYVKFKQS PGKFDYNKLL 60
EEPYGLKGTT ITGDTRSLEF LHNFFVELGK YDEALHVYER GNFKFPSYEL SYHWFMKALE 120
DSNYNQMSKA SLQLAKYSDS GNLPKRAYYF WNAISILAVS RFQENTLSDP KKILLSRLAR 180
QSLLDLKPFQ NVQEIIVYCL VLDELFPQSR EISEEIVAIT FANFDTSVNL YLKNFILKHT 240
KLLNSPQKLF EVCSKLIEKG LDDYELITNL IDAAYKLSKS KDEVKQWIDE NLGDSRNTRL 300
ARLKLDIMYT DSVSESSLSY YLSKYHNKPC CSIDLNHYSG HINIDMLKSI MSKYDPEDKD 360
LIHHCNILEL GLIGSDSINN YNKFKGTLEK KSVTDYSSCS TFLLEIVKDK CKKTNPELKD 420
VLLCITILEN YQAKDPHNFD TMCWLIVLYM YLGLVPDAYF HFINLKIKNV QTDSLDYMIF 480
SRFSTLFPNK QSDFYSKTFH EHNNLYDTSL ANLPRYIQVA FERNSYSKIL GMLEMRDKLM 540
KSYTRWTKTL ENLQFSRLCN DKRGHLLQKL HEDWRSLEMT QSVSFSDNRD FSILDENFAQ 600
FLNRGKILEY ANLNEESIFL TLIRELIIEA LPNGEKTEQI SALLKKLPSI NLEELLNNNL 660
TEVESASFLI FFEIYENNGK NLHDLISRLM KVPINAKQNW MVSHTYLTKM ATLKTLDSLK 720
RIKDKEIQKL IKNSLKELRS CCDDVFKGYS KALVQAYEEL KKDECGNLLK ELDVKAENVK 780
NIKNSLLGIQ KSVRNL 796 
Gene Ontology
 GO:0031416; C:NatB complex; IDA:UniProtKB.
 GO:0007010; P:cytoskeleton organization; IMP:SGD.
 GO:0000001; P:mitochondrion inheritance; IGI:SGD.
 GO:0017196; P:N-terminal peptidyl-methionine acetylation; IGI:SGD. 
Interpro
 IPR019183; N-acetylTrfase_B_cplx_non-cat. 
Pfam
 PF09797; NatB_MDM20 
SMART
  
PROSITE
  
PRINTS