CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000038
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal-regulatory protein beta-1 
Protein Synonyms/Alias
 SIRP-beta-1; CD172 antigen-like family member B; CD172b 
Gene Name
 SIRPB1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82RELIYNQKEGHFPRVubiquitination[1]
97TTVSELTKRNNLDFSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 
Sequence Annotation
 DOMAIN 30 136 Ig-like V-type.
 DOMAIN 147 246 Ig-like C1-type 1.
 DOMAIN 253 347 Ig-like C1-type 2.
 CARBOHYD 244 244 N-linked (GlcNAc...).
 CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
 CARBOHYD 291 291 N-linked (GlcNAc...) (Potential).
 DISULFID 54 120
 DISULFID 169 227 Potential.
 DISULFID 320 320 Interchain.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 398 AA 
Protein Sequence
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE DELQVIQPEK SVSVAAGESA TLRCAMTSLI 60
PVGPIMWFRG AGAGRELIYN QKEGHFPRVT TVSELTKRNN LDFSISISNI TPADAGTYYC 120
VKFRKGSPDD VEFKSGAGTE LSVRAKPSAP VVSGPAVRAT PEHTVSFTCE SHGFSPRDIT 180
LKWFKNGNEL SDFQTNVDPA GDSVSYSIHS TARVVLTRGD VHSQVICEIA HITLQGDPLR 240
GTANLSEAIR VPPTLEVTQQ PMRAENQANV TCQVSNFYPR GLQLTWLENG NVSRTETAST 300
LIENKDGTYN WMSWLLVNTC AHRDDVVLTC QVEHDGQQAV SKSYALEISA HQKEHGSDIT 360
HEAALAPTAP LLVALLLGPK LLLVVGVSAI YICWKQKA 398 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0045087; P:innate immune response; TAS:Reactome. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 
Pfam
 PF07654; C1-set
 PF07686; V-set 
SMART
 SM00409; IG
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE 
PRINTS