| Tag | Content |
|---|
| CPLM ID | CPLM-013983 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 21 |
Protein Synonyms/Alias | Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 21 |
Gene Name | ARHGAP21 |
Gene Synonyms/Alias | ARHGAP10; KIAA1424 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 25 | ACEVSKNKDGKEQSE | acetylation | [1] | | 28 | VSKNKDGKEQSETVS | acetylation | [1] | | 48 | TFSWPGPKTVTLKRT | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. |
Sequence Annotation | DOMAIN 49 158 PDZ.
DOMAIN 930 1039 PH.
DOMAIN 1146 1338 Rho-GAP.
REGION 929 1096 Interaction with ARF1 and ARF6.
REGION 1591 1860 Interaction with CTNNA1.
MOD_RES 35 35 Phosphoserine (By similarity).
MOD_RES 56 56 Phosphoserine.
MOD_RES 458 458 Phosphoserine.
MOD_RES 716 716 Phosphoserine.
MOD_RES 856 856 Phosphoserine.
MOD_RES 880 880 Phosphoserine (By similarity).
MOD_RES 923 923 Phosphoserine.
MOD_RES 1098 1098 Phosphoserine (By similarity).
MOD_RES 1430 1430 Phosphoserine (By similarity).
MOD_RES 1431 1431 Phosphoserine.
MOD_RES 1432 1432 Phosphoserine.
MOD_RES 1526 1526 Phosphoserine.
MOD_RES 1668 1668 Phosphoserine.
CROSSLNK 1443 1443 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Golgi apparatus; GTPase activation; Isopeptide bond; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1957 AA |
Protein Sequence | MATRRTGLSE GDGDKLKACE VSKNKDGKEQ SETVSLSEDE TFSWPGPKTV TLKRTSQGFG 60
FTLRHFIVYP PESAIQFSYK DEENGNRGGK QRNRLEPMDT IFVKQVKEGG PAFEAGLCTG 120
DRIIKVNGES VIGKTYSQVI ALIQNSDTTL ELSVMPKDED ILQVLQFTKD VTALAYSQDA 180
YLKGNEAYSG NARNIPEPPP ICYPWLPSAP SAMAQPVEIS PPDSSLSKQQ TSTPVLTQPG 240
RAYRMEIQVP PSPTDVAKSN TAVCVCNESV RTVIVPSEKV VDLLSNRNNH TGPSHRTEEV 300
RYGVSEQTSL KTVSRTTSPP LSIPTTHLIH QPAGSRSLEP SGILLKSGNY SGHSDGISSS 360
RSQAVEAPSV SVNHYSPNSH QHIDWKNYKT YKEYIDNRRL HIGCRTIQER LDSLRAASQS 420
TTDYNQVVPN RTTLQGRRRS TSHDRVPQSV QIRQRSVSQE RLEDSVLMKY CPRSASQGAL 480
TSPSVSFSNH RTRSWDYIEG QDETLENVNS GTPIPDSNGE KKQTYKWSGF TEQDDRRGIC 540
ERPRQQEIHK SFRGSNFTVA PSVVNSDNRR MSGRGVGSVS QFKKIPPDLK TLQSNRNFQT 600
TCGMSLPRGI SQDRSPLVKV RSNSLKAPST HVTKPSFSQK SFVSIKDQRP VNHLHQNSLL 660
NQQTWVRTDS APDQQVETGK SPSLSGASAK PAPQSSENAG TSDLELPVSQ RNQDLSLQEA 720
ETEQSDTLDN KEAVILREKP PSGRQTPQPL RHQSYILAVN DQETGSDTTC WLPNDARREV 780
HIKRMEERKA SSTSPPGDSL ASIPFIDEPT SPSIDHDIAH IPASAVISAS TSQVPSIATV 840
PPCLTTSAPL IRRQLSHDHE SVGPPSLDAQ PNSKTERSKS YDEGLDDYRE DAKLSFKHVS 900
SLKGIKIADS QKSSEDSGSR KDSSSEVFSD AAKEGWLHFR PLVTDKGKRV GGSIRPWKQM 960
YVVLRGHSLY LYKDKREQTT PSEEEQPISV NACLIDISYS ETKRKNVFRL TTSDCECLFQ 1020
AEDRDDMLAW IKTIQESSNL NEEDTGVTNR DLISRRIKEY NNLMSKAEQL PKTPRQSLSI 1080
RQTLLGAKSE PKTQSPHSPK EESERKLLSK DDTSPPKDKG TWRKGIPSIM RKTFEKKPTA 1140
TGTFGVRLDD CPPAHTNRYI PLIVDICCKL VEERGLEYTG IYRVPGNNAA ISSMQEELNK 1200
GMADIDIQDD KWRDLNVISS LLKSFFRKLP EPLFTNDKYA DFIEANRKED PLDRLKTLKR 1260
LIHDLPEHHY ETLKFLSAHL KTVAENSEKN KMEPRNLAIV FGPTLVRTSE DNMTHMVTHM 1320
PDQYKIVETL IQHHDWFFTE EGAEEPLTTV QEESTVDSQP VPNIDHLLTN IGRTGVSPGD 1380
VSDSATSDST KSKGSWGSGK DQYSRELLVS SIFAAASRKR KKPKEKAQPS SSEDELDNVF 1440
FKKENVEQCH NDTKEESKKE SETLGRKQKI IIAKENSTRK DPSTTKDEKI SLGKESTPSE 1500
EPSPPHNSKH NKSPTLSCRF AILKESPRSL LAQKSSHLEE TGSDSGTLLS TSSQASLARF 1560
SMKKSTSPET KHSEFLANVS TITSDYSTTS SATYLTSLDS SRLSPEVQSV AESKGDEADD 1620
ERSELISEGR PVETDSESEF PVFPTALTSE RLFRGKLQEV TKSSRRNSEG SELSCTEGSL 1680
TSSLDSRRQL FSSHKLIECD TLSRKKSARF KSDSGSLGDA KNEKEAPSLT KVFDVMKKGK 1740
STGSLLTPTR GESEKQEPTW KTKIADRLKL RPRAPADDMF GVGNHKVNAE TAKRKSIRRR 1800
HTLGGHRDAT EISVLNFWKV HEQSGERESE LSAVNRLKPK CSAQDLSISD WLARERLRTS 1860
TSDLSRGEIG DPQTENPSTR EIATTDTPLS LHCNTGSSSS TLASTNRPLL SIPPQSPDQI 1920
NGESFQNVSK NASSAANAQP HKLSETPGSK AEFHPCL 1957 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IDA:BHF-UCL. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0051683; P:establishment of Golgi localization; IDA:BHF-UCL. GO:0007030; P:Golgi organization; IMP:BHF-UCL. GO:0051684; P:maintenance of Golgi location; IMP:BHF-UCL. GO:0072384; P:organelle transport along microtubule; IMP:BHF-UCL. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |