UniProt Accession

 RL1A_YEAST; P0CX43; D6VU14; P53030 

Genbank Protein ID

 X70985; Z73576; BK006949 

Genbank Nucleotide ID

 CAA50314.1; CAA97935.1; DAA11216.1 

Protein Name

 60S ribosomal protein L1-A 

Protein Synonyms/Alias

 L10a 

Gene Name

 RPL1A 

Gene Synonyms/Alias

 SSM1; SSM1A; YPL220W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKITSSQVR	acetylation	[1]
14	SQVREHVKELLKYSN	acetylation	[1]
18	EHVKELLKYSNETKK	acetylation	[1]
18	EHVKELLKYSNETKK	ubiquitination	[2]
47	NYDPQRDKRFSGSLK	methylation	[3]
54	KRFSGSLKLPNCPRP	ubiquitination	[2]
78	AFDVDRAKSCGVDAM	ubiquitination	[2]
91	AMSVDDLKKLNKNKK	acetylation	[1]
118	IASEVLIKQVPRLLG	acetylation	[1]
130	LLGPQLSKAGKFPTP	acetylation	[1]
130	LLGPQLSKAGKFPTP	ubiquitination	[2]
133	PQLSKAGKFPTPVSH	acetylation	[1]
147	HNDDLYGKVTDVRST	acetylation	[1]
147	HNDDLYGKVTDVRST	ubiquitination	[2]
156	TDVRSTIKFQLKKVL	acetylation	[1]
196	FFVSLLKKNWQNVGS	acetylation	[1]
207	NVGSLVVKSSMGPAF	methylation	[4]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase.
 Webb KJ, Al-Hadid Q, Zurita-Lopez CI, Young BD, Lipson RS, Clarke SG.
 J Biol Chem. 2011 May 27;286(21):18405-13. [PMID: 21460220]
 [4] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074] 

Functional Description

  

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 47 47 N6-methyllysine; by RKM5.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 86 86 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Methylation; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD. 

Interpro

 IPR002143; Ribosomal_L1.
 IPR016094; Ribosomal_L1_2-a/b-sand.
 IPR016095; Ribosomal_L1_3-a/b-sand.
 IPR023673; Ribosomal_L1_CS.
 IPR023674; Ribosomal_L1_SF. 

Pfam

 PF00687; Ribosomal_L1 

SMART

  

PROSITE

 PS01199; RIBOSOMAL_L1 

PRINTS