UniProt Accession

 YPT52_YEAST; P36018; D6VX79 

Genbank Protein ID

 X76174; Z28239; BK006944 

Genbank Nucleotide ID

 CAA53770.1; CAA82086.1; DAA09169.1 

Protein Name

 GTP-binding protein YPT52 

Protein Synonyms/Alias

  

Gene Name

 YPT52 

Gene Synonyms/Alias

 YKR014C; YK112 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
151	EGGDEEQKVRAISTE	ubiquitination	[1, 2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 66 70 GTP (By similarity).
 NP_BIND 111 114 GTP (By similarity).
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 142 142 Phosphoserine.
 LIPID 232 232 S-geranylgeranyl cysteine (By
 LIPID 233 233 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IMP:SGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0006895; P:Golgi to endosome transport; IMP:SGD.
 GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IGI:SGD.
 GO:0036258; P:multivesicular body assembly; IGI:SGD.
 GO:0036010; P:protein localization to endosome; IGI:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.