CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003514
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetylglucosamine repressor 
Protein Synonyms/Alias
  
Gene Name
 nagC 
Gene Synonyms/Alias
 nagR; b0676; JW0662 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
63LIERGLIKEVDQQASacetylation[1]
108TLFDLSSKVLAEEHYacetylation[1]
283QRVLNLLKQGYQSRVacetylation[1]
298PLDDCTIKTICKAANacetylation[2]
302CTIKTICKAANKGDSacetylation[1]
306TICKAANKGDSLASEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 
Functional Description
 Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. 
Sequence Annotation
 DNA_BIND 35 44 H-T-H motif (By similarity).  
Keyword
 Activator; Carbohydrate metabolism; Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MTPGGQAQIG NVDLVKQLNS AAVYRLIDQY GPISRIQIAE QSQLAPASVT KITRQLIERG 60
LIKEVDQQAS TGGRRAISIV TETRNFHAIG VRLGRHDATI TLFDLSSKVL AEEHYPLPER 120
TQQTLEHALL NAIAQFIDSY QRKLRELIAI SVILPGLVDP DSGKIHYMPH IQVENWGLVE 180
ALEERFKVTC FVGHDIRSLA LAEHYFGASQ DCEDSILVRV HRGTGAGIIS NGRIFIGRNG 240
NVGEIGHIQV EPLGERCHCG NFGCLETIAA NAAIEQRVLN LLKQGYQSRV PLDDCTIKTI 300
CKAANKGDSL ASEVIEYVGR HLGKTIAIAI NLFNPQKIVI AGEITEADKV LLPAIESCIN 360
TQALKAFRTN LPVVRSELDH RSAIGAFALV KRAMLNGILL QHLLEN 406 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000600; ROK.
 IPR000835; Tscrpt_reg_HTH_MarR-typ.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01047; MarR
 PF00480; ROK 
SMART
  
PROSITE
 PS01125; ROK 
PRINTS