CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008383
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SWI5-dependent HO expression protein 4 
Protein Synonyms/Alias
  
Gene Name
 SHE4 
Gene Synonyms/Alias
 YOR035C; OR26.26 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
28AAFDKTLKSTPDVQKubiquitination[1]
170KEVRFLVKELILRISacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for mother cell-specific ho expression. Might be required for the transport of factors (such as ASH1) that promote HO repression from the mother cell into its bud. 
Sequence Annotation
 MOD_RES 18 18 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 789 AA 
Protein Sequence
MPLCEKGNDP IDSSTIDSLC AAFDKTLKST PDVQKYNDAI NTIFQLRQKS ESGKMPADLT 60
NSEALKDRQK IEEILTRSYQ DHSESRVHLS KLIQNDIPFA LNLFEILSRS SIHVFVGCFS 120
NKDATIALLN ELQIRIHYGE DTHVTYLLSI ILQLLNKFKY NFKEVRFLVK ELILRISEDE 180
VKSMMLIIFA ELQSSFQKDF DKAVVDFMSS LIVEAEIDVG NDPLSIIVKT LSELYPSLTT 240
LCSEIFLTKG LSKLFKKRVF EEQDLQFTKE LLRLLSSACI DETMRTYITE NYLQLLERSL 300
NVEDVQIYSA LVLVKTWSFT KLTCINLKQL SEIFINAISR RIMPKIENVN ESAVKLEEVP 360
KVEMSVEALA YLSLKASVKI MIRSNESFTE ILLTMIKSQK MTHCLYGLLV IMANLSTLPE 420
ESNGSSQSIN DLKNYADLKG PGADKVGAEK ESKEDILLFN EKYILRTELI SFLKREMHNL 480
SPNCKQQVVR VIYNITRSKN FIPQCISQGG TTIILEYLAN KQDIGEPIRI LGCRALTRML 540
IFTNPGLIFK KYSALNAIPF LFELLPRSTP VDDNPLHNDE QIKLTDNYEA LLALTNLASS 600
ETSDGEEVCK HIVSTKVYWS TIENLMLDEN VPLQRSTLEL ISNMMSHPLT IAAKFFNLEN 660
PQSLRNFNIL VKLLQLSDVE SQRAVAAIFA NIATTIPLIA KELLTKKELI ENAIQVFADQ 720
IDDIELRQRL LMLFFGLFEV IPDNGTNEVY PLLQENQKLK DALNMSLKRG DSGPEFSAAI 780
PVILAKIKV 789 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0017022; F:myosin binding; IDA:SGD.
 GO:0030036; P:actin cytoskeleton organization; TAS:SGD.
 GO:0008298; P:intracellular mRNA localization; IMP:SGD.
 GO:0007533; P:mating type switching; IMP:SGD. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR024660; UNC-45/Ring3. 
Pfam
 PF11701; UNC45-central 
SMART
  
PROSITE
  
PRINTS