CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024080
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polypyrimidine tract-binding protein 3 
Protein Synonyms/Alias
 Regulator of differentiation 1; Rod1 
Gene Name
 Ptbp3 
Gene Synonyms/Alias
 Rod1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
394SGQRLYGKVLRATLSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity). 
Sequence Annotation
 DOMAIN 30 114 RRM 1.
 DOMAIN 153 229 RRM 2.
 DOMAIN 329 403 RRM 3.
 DOMAIN 446 521 RRM 4.
 MOD_RES 394 394 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Differentiation; Erythrocyte maturation; mRNA processing; mRNA splicing; Reference proteome; Repeat; Repressor; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MNNSTSAGVY ANGNDNKKFK GDRPPCSPSR VLHLRKIPCD VTEAEVISLG LPFGKVTNLL 60
MLKGKSQAFL EMASEEAAVT MINYYTPVTP HLRSQPVYIQ YSNHRELKTD NLPNQARAQA 120
ALQAVSAVQS GNLSLPGATS NEGTLLPGQS PVLRIIIENL FYPVTLEVLH QIFSKFGTVL 180
KIITFTKNNQ FQALLQYADP VNAQYAKMAL DGQNIYNACC TLRIDFSKLT SLNVKYNNDK 240
SRDFTRLDLP TGDGQPSLEP PMAAAFGAPG IMSSPYAGAA GFAPAIAFPQ AAGLSVSAVP 300
GALGPLTLTS SAVSGRMAIP GASGIPGNSV LLVTNLNPDF ITPHGLFILF GVYGDVHRVK 360
IMFNKKENAL VQMADASQAQ IAMNHLSGQR LYGKVLRATL SKHQAVQLPR EGQEDQGLTK 420
DFSNSPLHRF KKPGSKNFQN IFPPSATLHL SNIPPSVTMD DLKNLFTEAG CSVKAFKFFQ 480
KDRKMALIQL GSVEEAIQAL IELHNHDLGE NHHLRVSFSK STI 523 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; NAS:RGD.
 GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0033119; P:negative regulation of RNA splicing; IEA:Compara.
 GO:0045595; P:regulation of cell differentiation; IMP:RGD.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR006536; HnRNP-L_PTB.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS