| Tag | Content |
|---|
| CPLM ID | CPLM-016459 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 10B |
Protein Synonyms/Alias | Protein wz3-85 |
Gene Name | Tbc1d10b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 354 | IPSSLRAKAWQYLSN | ubiquitination | [1] | | 372 | LLEQNPGKFEELERA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (By similarity). |
Sequence Annotation | DOMAIN 346 534 Rab-GAP TBC.
MOD_RES 644 644 Phosphoserine (By similarity).
MOD_RES 647 647 Phosphoserine (By similarity).
MOD_RES 664 664 Phosphoserine.
MOD_RES 673 673 Phosphoserine.
MOD_RES 693 693 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 798 AA |
Protein Sequence | METGPAPLVA PPRRHGAPAA PSPPPRGSRA GSHLVVEPGP PVTTATSAPV ELVAPGEARP 60
ACVPGSSQTS ASTPTTATSS TVVMLTLEAS PEAAKTQEFP APAAETGAET SVALALGTDT 120
QKTEEVRASP VPGPGTPTRT PSRMAPGALT AKPPLAPKPG TTVASGVTAR GGVGQVAGGH 180
EAATSASAGS VPEDPSGPVT GPPGTCEAPA PTPVAVVTVT PAPEPVENFQ DLGSTSSLGP 240
GISGPRGQAP DTLSYLDSVS LMSGTLESLP DDVSSMGSDS EINGMALRKT DKYGFLGGSQ 300
YSGSLESSIP VDVARQRELK WLEMFSNWDK WLSRRFQKVK LRCRKGIPSS LRAKAWQYLS 360
NSKELLEQNP GKFEELERAA GDPKWLDVIE KDLHRQFPFH EMFAARGGHG QQDLYRILKA 420
YTIYRPDEGY CQAQAPVAAV LLMHMPAEQA FWCLVQICDK YLPGYYSAGL EAIQLDGEIF 480
FALLRRVSPL AHRHLRRQRI DPVLYMTEWF MCIFARTLPW ASVLRVWDMF FCEGVKIIFR 540
VALVLLRHTL GSVEKLRSCQ GMYETMEQLR NLPQQCMQED FLVHEVTNLP VTEAWIEREN 600
AAQLKKWRET RGELQYRPSR RLHGSRAIHE ERRRQQPPLG PSSSLLSLPS LKSRGSRAVG 660
GAPSPPPPVR RASAGPVPGA VVIAEGLHPS LPSPTGNSTP LGTSKEIRRQ EKERQKQEKD 720
REKERQRQEK ERERQEKERQ KWEKEQEKEQ QKQEKERQKL EKKGQGRKLS LRRRADGPPA 780
SHDGGDRSAA EARQDAYF 798 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005097; F:Rab GTPase activator activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |