UniProt Accession

 MBD2_MOUSE; Q9Z2E1; E9QMV9; Q811D9; Q9Z2D9 

Genbank Protein ID

 AF072243; AF072245; AF120986; AF120983; AF120984; AF120985; AF120983; AC134831; AC166815; AC170591; BC046607 

Genbank Nucleotide ID

 AAC68872.1; AAC68874.1; AAD50372.1; AAD50372.1; AAD50372.1; AAD50372.1; AAD50373.1; AAH46607.2 

Protein Name

 Methyl-CpG-binding domain protein 2 

Protein Synonyms/Alias

 Methyl-CpG-binding protein MBD2 

Gene Name

 Mbd2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
188	YYFSPSGKKFRSKPQ	acetylation	[1]
188	YYFSPSGKKFRSKPQ	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters. 

Sequence Annotation

 DOMAIN 148 216 MBD.
 MOD_RES 184 184 Phosphoserine (By similarity).
 MOD_RES 410 410 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0000792; C:heterochromatin; IDA:MGI.
 GO:0000118; C:histone deacetylase complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0008327; F:methyl-CpG binding; IDA:MGI.
 GO:0003729; F:mRNA binding; IDA:MGI.
 GO:0035197; F:siRNA binding; IDA:MGI.
 GO:0043623; P:cellular protein complex assembly; IMP:MGI.
 GO:0042711; P:maternal behavior; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IGI:MGI.
 GO:0042127; P:regulation of cell proliferation; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016177; DNA-bd_integrase-typ.
 IPR025884; MeCpG-bd_2/3_C_dom.
 IPR001739; Methyl_CpG_DNA-bd. 

Pfam

 PF01429; MBD
 PF14048; MBD_C 

SMART

 SM00391; MBD 

PROSITE

 PS50982; MBD 

PRINTS