UniProt Accession

 CENPW_HUMAN; Q5EE01; A6NIR0; A6NJC2 

Genbank Protein ID

 AY902475; AC020559; CH471051; CH471051; CH471051; BC017928; BC039556; BC046178; BC062798 

Genbank Nucleotide ID

 AAW82474.1; EAW48121.1; EAW48122.1; EAW48123.1; AAH17928.1; AAH39556.1; AAH46178.1; AAH62798.1 

Protein Name

 Centromere protein W 

Protein Synonyms/Alias

 CENP-W; Cancer-up-regulated gene 2 protein 

Gene Name

 CENPW 

Gene Synonyms/Alias

 C6orf173; CUG2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	SKCRVINKEHVLAAA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. 

Sequence Annotation

  

Keyword

 Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; DNA-binding; Kinetochore; Mitosis; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:UniProtKB.
 GO:0007059; P:chromosome segregation; IMP:UniProtKB.
 GO:0051382; P:kinetochore assembly; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; IMP:UniProtKB. 

Interpro

 IPR009072; Histone-fold. 

Pfam

  

SMART

  

PROSITE

  

PRINTS