UniProt Accession

 D103A_HUMAN; P81534; Q8NFG6; Q9NPF6 

Genbank Protein ID

 AJ237673; AF295370; AF217245; AB037972; AF301470; AF516673 

Genbank Nucleotide ID

 CAC03097.1; AAG02237.1; AAF73853.1; BAB40572.1; AAG22030.1; AAM62424.1 

Protein Name

 Beta-defensin 103 

Protein Synonyms/Alias

 Beta-defensin 3; BD-3; DEFB-3; HBD3; hBD-3; Defensin, beta 103; Defensin-like protein 

Gene Name

 DEFB103A; DEFB103B 

Gene Synonyms/Alias

 BD3; DEFB103; DEFB3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	GIINTLQKYYCRVRG	acetylation	[1]
48	AVLSCLPKEEQIGKC	acetylation	[1]
54	PKEEQIGKCSTRGRK	acetylation	[1]
61	KCSTRGRKCCRRKK*	acetylation	[1]
66	GRKCCRRKK******	acetylation	[1]
67	RKCCRRKK*******	acetylation	[1]

Reference

 [1] Role of acetylation and charge in antimicrobial peptides based on human beta-defensin-3.
 Papanastasiou EA, Hua Q, Sandouk A, Son UH, Christenson AJ, Van Hoek ML, Bishop BM.
 APMIS. 2009 Jul;117(7):492-9. [PMID: 19594489] 

Functional Description

 Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. 

Sequence Annotation

 DISULFID 33 62
 DISULFID 40 55
 DISULFID 45 63  

Keyword

 3D-structure; Antibiotic; Antimicrobial; Complete proteome; Defensin; Direct protein sequencing; Disulfide bond; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 67 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005796; C:Golgi lumen; TAS:Reactome.
 GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0006965; P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; TAS:UniProtKB. 

Interpro

 IPR001855; Defensin_beta-typ. 

Pfam

 PF00711; Defensin_beta 

SMART

  

PROSITE

  

PRINTS