CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013121
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 1 regulatory subunit 7 
Protein Synonyms/Alias
 Protein phosphatase 1 regulatory subunit 22 
Gene Name
 Ppp1r7 
Gene Synonyms/Alias
 Sds22 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
134DLYDNQIKKIENLEAacetylation[1]
163RNIEGIDKLTQLKKLubiquitination[2]
169DKLTQLKKLFLVNNKubiquitination[2]
176KLFLVNNKINKIENIubiquitination[2]
218LESLFLGKNKITKLQubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Regulatory subunit of protein phosphatase 1 (By similarity). 
Sequence Annotation
 REPEAT 78 99 LRR 1.
 REPEAT 100 121 LRR 2.
 REPEAT 122 143 LRR 3.
 REPEAT 144 165 LRR 4.
 REPEAT 166 187 LRR 5.
 REPEAT 188 209 LRR 6.
 REPEAT 210 231 LRR 7.
 REPEAT 232 253 LRR 8.
 REPEAT 254 275 LRR 9.
 REPEAT 276 297 LRR 10.
 REPEAT 298 319 LRR 11.
 DOMAIN 332 361 LRRCT.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 24 24 Phosphoserine.
 MOD_RES 27 27 Phosphoserine.
 MOD_RES 45 45 Phosphoserine (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 361 AA 
Protein Sequence
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHGGGGI VANLSEQSLK DGVDRGAEDP 60
EEEHELAVDM ETINLDRDAE DVDLTHYRIG KIEGLEVLKK VKSLCLRQNL IKCIENLEEL 120
QSLRELDLYD NQIKKIENLE ALTELEVLDI SFNMLRNIEG IDKLTQLKKL FLVNNKINKI 180
ENISNLHQLQ MLELGSNRIR AIENIDTLTN LESLFLGKNK ITKLQNLDAL TNLTVLSVQS 240
NRLAKIEGLQ SLVNLRELYL SNNGIEVIEG LENNNKLTML DIASNRIKKI ENISHLTELQ 300
EFWMNDNLLE SWSDLDELKG ARSLETVYLE RNPLQKDPQY RRKVMLALPS VRQIDATYVR 360
F 361 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003603; U2A'_phosphoprotein32A_C. 
Pfam
 PF12799; LRR_4 
SMART
 SM00446; LRRcap 
PROSITE
 PS51450; LRR 
PRINTS