UniProt Accession

 RYBP_MOUSE; Q8CCI5; B2RRB6; Q9WVK2 

Genbank Protein ID

 AK033024; BC053016; BC080287; BC138324; BC138325; AF101779 

Genbank Nucleotide ID

 BAC28131.1; AAH53016.1; AAH80287.1; AAI38325.1; AAI38326.1; AAD42945.1 

Protein Name

 RING1 and YY1-binding protein 

Protein Synonyms/Alias

 Death effector domain-associated factor; DED-associated factor 

Gene Name

 Rybp 

Gene Synonyms/Alias

 Dedaf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
136	QSANATTKTSETNHT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity). 

Sequence Annotation

 ZN_FING 21 50 RanBP2-type.
 REGION 143 226 Interaction with E4TF1B (By similarity).
 MOD_RES 99 99 Phosphoserine (By similarity).
 MOD_RES 127 127 Phosphoserine (By similarity).
 MOD_RES 130 130 Phosphoserine (By similarity).
 MOD_RES 227 227 Phosphoserine (By similarity).  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IDA:MGI.
 GO:0031519; C:PcG protein complex; IEA:Compara.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0035518; P:histone H2A monoubiquitination; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001876; Znf_RanBP2. 

Pfam

 PF00641; zf-RanBP 

SMART

 SM00547; ZnF_RBZ 

PROSITE

 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 

PRINTS