| Tag | Content |
|---|
| CPLM ID | CPLM-017290 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase HECW1 |
Protein Synonyms/Alias | HECT, C2 and WW domain-containing protein 1; NEDD4-like E3 ubiquitin-protein ligase 1; mNEDL1 |
Gene Name | Hecw1 |
Gene Synonyms/Alias | Kiaa0322; Nedl1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 300 | IIKRFLGKLSMPVQR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1 (By similarity). |
Sequence Annotation | DOMAIN 192 302 C2.
DOMAIN 826 859 WW 1.
DOMAIN 1016 1049 WW 2.
DOMAIN 1269 1604 HECT.
ACT_SITE 1572 1572 Glycyl thioester intermediate (By |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Ligase; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1604 AA |
Protein Sequence | MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN IDIRNGAHDA 60
ITIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIGEV 120
SSENFLDYKN RGVNGSHRGQ IIWKIDASSY FVESETKICF KYYHGVSGAL RATTPSVTVK 180
NSAAPIFKGI GSEETAQSQG SRRLISFSLS DFQAMGLKKG MFFNPDPYLK ISIQPGKHSI 240
FPALPHHGQE RRSTIIGNTV NPIWQAEHFS FVSLPTDVLE IEVKDKFAKS RPIIKRFLGK 300
LSMPVQRLLE RHAIGDRVVS YTLGRRLPTD HVSGQLQFRF EITSSIHADD EEISLSAEPE 360
SSAETQDSIM NSMVGNSNGE PSGDATEFCK DAKPESPSEG NGVNSSENQN QEHAGPVEEA 420
AGAMEARDGS NVSEAPEEPG ELQDPEQHDT QPTLSAEEVA EGLPLDEDSP SSLLPEENTA 480
LGSKVEEETV PENGAREEEM QKGKDEEEEE EDVSTLEQGE PGLELRVSVR KKSRPCSLPV 540
SELETVIASA CGDAETPRTH YIRIHTLLHS MPSAQRGSTT EEEDGLEEES TLKESSEKDG 600
LSEVDTIAAD PQSMEDGESD GATLCMAPSD CSGGHFSSLS KGIGAGQDGE AHPSTGSESD 660
SSPQQGADHS CEGCDASCCS PSCYSTSCYS SSCYSSSCYS SSCYNGNNRF ASHTRFSSVD 720
SAKISESTVF SSQEDEEEEN SAFESVPDSV QSPELDPEST NGAGPWQDEL AAPGGNAARS 780
TEGLESPMAG PSNRREGECP ILHNSQPISQ LPSLRPEHHH YPTIDEPLPP NWEARIDSHG 840
RVFYVDHINR TTTWQRPSMA PTPDGMIRSG SVHQMEQLNR RYQNIQRTMA TERAEEDSGN 900
QNSEQIPDGG GGGGGGSDSE AESSQSSLDL RREGSLSPVN SQKVTLLLQS PAVKFITNPE 960
FFTVLHANYS AYRVFTSSTC LKHMILKVRR DARNFERYQH NRDLVNFINM FADTRLELPR 1020
GWEIKTDHQG KSFFVDHNSR ATTFIDPRIP LQNGRLPNHL THRQHLQRLR SYSAGEASEV 1080
SRNRGASLLA RPGHSLIAAI RSQHQHESLP LAYNDKIVAF LRQPNIFEML QERQPSLARN 1140
HTLREKIHYI RTEGNHGLDK LSCDADLVIL LSLFEEEIMS YVPLQSAFHP GYSFSPRCSP 1200
CSSPQNSPGL QRASARAPSP YRRDFEAKLR NFYRKLEAKG FGQGPGKIKL IIRRDHLLEG 1260
TFNQVMAYSR KELQRNKLYI TFVGEEGLDY SGPSREFFFL LSQELFNPYY GLFEYSANDT 1320
YTVQISPMSA FVENYLEWFR FSGRILGLAL IHQYLLDAFF TRPFYKGLLK LPCDLSDLEY 1380
LDEEFHQSLQ WMKDNNITDI LDLTFTVNEE VFGQVTEREL KSGGANTQVT EKNKKEYIER 1440
MVKWRVERGV VQQTEALLRG FYEVVDSRLV SVFDARELEL VIAGTAEIDL NDWRNNTEYR 1500
GGYHDGHLVI RWFWAAVERF NNEQRLRLLQ FVTGTSSVPY EGFAALRGSN GLRRFCIEKW 1560
GKITSLPRAH TCFNRLDLPP YPSYSMLYEK LLTAVEETST FGLE 1604 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |