UniProt Accession

 ST1B1_MOUSE; Q9QWG7; Q8C301; Q9Z2T0 

Genbank Protein ID

 U92076; AF022894; AK033498; AK087595; BC024361 

Genbank Nucleotide ID

 AAD09249.1; AAD01746.1; BAC28321.1; BAC39939.1; AAH24361.1 

Protein Name

 Sulfotransferase family cytosolic 1B member 1 

Protein Synonyms/Alias

 ST1B1; Sulfotransferase 1B1; DOPA/tyrosine sulfotransferase 

Gene Name

 Sult1b1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
107	TPSPRIIKTHLPIDL	ubiquitination	[1]
253	TAMMDHSKSPFMRKG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates L-DOPA and D-DOPA, tyrosine isomers such as DL-m-tyrosine, dopamine and thyroid hormones. 

Sequence Annotation

 NP_BIND 48 53 PAPS (By similarity).
 NP_BIND 228 233 PAPS (By similarity).
 NP_BIND 258 260 PAPS (By similarity).
 ACT_SITE 109 109 Proton acceptor (By similarity).
 BINDING 131 131 PAPS (By similarity).
 BINDING 139 139 PAPS (By similarity).
 BINDING 194 194 PAPS (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Lipid metabolism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:MGI.
 GO:0004062; F:aryl sulfotransferase activity; IDA:MGI.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
 GO:0051923; P:sulfation; IEA:Compara.
 GO:0042403; P:thyroid hormone metabolic process; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS