CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041552
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoplasmic aconitate hydratase 
Protein Synonyms/Alias
 RCG55067 
Gene Name
 Aco1 
Gene Synonyms/Alias
 rCG_55067 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
19LDPAQPGKKFFNLNKacetylation[1]
20DPAQPGKKFFNLNKLacetylation[1]
26KKFFNLNKLEDSRYGacetylation[1]
79KSIEVPFKPARVILQacetylation[1]
141RRADSLQKNQDLEFEacetylation[1]
266DIVLTITKHLRQVGVacetylation[1]
379GPKRPQDKVAVSEMKacetylation[1]
396FESCLGAKQGFKGFQacetylation[1]
464VEAGLNVKPYVKTSLacetylation[1]
610YVIPGMFKEVYQKIEacetylation[1]
615MFKEVYQKIETVNKSacetylation[1]
621QKIETVNKSWNALAAacetylation[1]
621QKIETVNKSWNALAAubiquitination[2]
632ALAAPSEKLYAWNPKacetylation[1]
639KLYAWNPKSTYIKSPacetylation[1]
736LLNKFLNKQAPQTVHacetylation[1]
844IHIPEDLKPRMKVQIacetylation[1]
848EDLKPRMKVQIKLDTacetylation[1]
852PRMKVQIKLDTGKTFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 889 AA 
Protein Sequence
MKNPFAHLAE PLDPAQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAVRNC DEFLVKKNDI 60
ENILNWSIMQ HKSIEVPFKP ARVILQDFTG VPAVVDFAAM RDAVKKLGGN PEKINPVCPA 120
DLVIDHSIQV DFNRRADSLQ KNQDLEFERN RERFEFLKWG SQAFCNMRII PPGSGIIHQV 180
NLEYLARVVF DQDGCYYPDS LVGTDSHTTM IDGLGVLGWG VGGIEAEAVM LGQPISMVLP 240
QVIGYKLMGK PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI ADRATIANMC 300
PEYGATAAFF PVDNVSIAYL VQTGREEDKV KHIKRYLQAV GMFRDFSDSS QDPDFTQVVE 360
LDLKTVVPCC SGPKRPQDKV AVSEMKRDFE SCLGAKQGFK GFQVAPDHHN DHKTFIYNDS 420
EFTLAHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVEAG LNVKPYVKTS LSPGSGVVTY 480
YLRESGVMPY LSQLGFDVVG YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG VLSGNRNFEG 540
RVHPNTRANY LASPPLVIAY AIAGTVRIDF EKEPLGVNAQ GQQVFLKDIW PTRDEIQEVE 600
RKYVIPGMFK EVYQKIETVN KSWNALAAPS EKLYAWNPKS TYIKSPPFFE SLTLDLQPPK 660
SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG LTPRDFNSYG SRRGNDAIMA 720
RGTFANIRLL NKFLNKQAPQ TVHLPSGETL DVFDAAERYQ QAGLPLIVLA GKEYGSGSSR 780
DWAAKGPFLL GIKAVLAESY ERIHRSNLVG MGVIPLEYLP GETADSLGLT GRERYTIHIP 840
EDLKPRMKVQ IKLDTGKTFQ AVMRFDTDVE LTYFHNGGIL NYMIRKMAQ 889 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0003994; F:aconitate hydratase activity; IEA:Compara.
 GO:0030350; F:iron-responsive element binding; IEA:Compara.
 GO:0006879; P:cellular iron ion homeostasis; IEA:Compara.
 GO:0006101; P:citrate metabolic process; IEA:Compara.
 GO:0050892; P:intestinal absorption; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006417; P:regulation of translation; IEA:Compara.
 GO:0010040; P:response to iron(II) ion; IEA:Compara. 
Interpro
 IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
 IPR015937; Acoase/IPM_deHydtase.
 IPR001030; Acoase/IPM_deHydtase_lsu_aba.
 IPR015928; Aconitase/3IPM_dehydase_swvl.
 IPR006249; Aconitase/Fe_reg_prot_2.
 IPR015934; Aconitase/Fe_reg_prot_2/AcnD.
 IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
 IPR018136; Aconitase_4Fe-4S_BS.
 IPR000573; AconitaseA/IPMdHydase_ssu_swvl. 
Pfam
 PF00330; Aconitase
 PF00694; Aconitase_C 
SMART
  
PROSITE
 PS00450; ACONITASE_1
 PS01244; ACONITASE_2 
PRINTS
 PR00415; ACONITASE.