| Tag | Content |
|---|
| CPLM ID | CPLM-003816 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic initiation factor 4A-II |
Protein Synonyms/Alias | eIF-4A-II; eIF4A-II; ATP-dependent RNA helicase eIF4A-2 |
Gene Name | Eif4a2 |
Gene Synonyms/Alias | Ddx2b |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | NVRNEMQKLQAEAPH | ubiquitination | [1] | | 176 | NRRYLSPKWIKMFVL | ubiquitination | [1] | | 311 | LHGDMDQKERDVIMR | ubiquitination | [1] | | 383 | NFVTEEDKRILRDIE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. |
Sequence Annotation | DOMAIN 64 235 Helicase ATP-binding.
DOMAIN 246 407 Helicase C-terminal.
NP_BIND 77 84 ATP (By similarity).
MOTIF 33 61 Q motif.
MOTIF 183 186 DEAD box. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Helicase; Hydrolase; Initiation factor; Nucleotide-binding; Protein biosynthesis; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 407 AA |
Protein Sequence | MSGGSADYNS REHGGPEGMD PDGVIESNWN EIVDNFDDMN LKESLLRGIY AYGFEKPSAI 60
QQRAIIPCIK GYDVIAQAQS GTGKTATFAI SILQQLEIEF KETQALVLAP TRELAQQIQK 120
VILALGDYMG ATCHACIGGT NVRNEMQKLQ AEAPHIVVGT PGRVFDMLNR RYLSPKWIKM 180
FVLDEADEML SRGFKDQIYE IFQKLNTSIQ VVLLSATMPT DVLEVTKKFM RDPIRILVKK 240
EELTLEGIKQ FYINVEREEW KLDTLCDLYE TLTITQAVIF LNTRRKVDWL TEKMHARDFT 300
VSALHGDMDQ KERDVIMREF RSGSSRVLIT TDLLARGIDV QQVSLVINYD LPTNRENYIH 360
RIGRGGRFGR KGVAINFVTE EDKRILRDIE TFYNTTVEEM PMNVADLI 408 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |