UniProt Accession

 RBM38_MOUSE; Q62176; Q5U418; Q922Z2 

Genbank Protein ID

 X75316; AK146026; AK162141; AK172625; AL928599; CH466551; BC085307 

Genbank Nucleotide ID

 CAA53065.1; BAE26841.1; BAE36749.1; BAE43103.1; CAM22369.1; EDL06620.1; AAH85307.1 

Protein Name

 RNA-binding protein 38 

Protein Synonyms/Alias

 RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4 

Gene Name

 Rbm38 

Gene Synonyms/Alias

 Rnpc1; Seb4; Seb4l 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
112	NLAYLGAKPRSLQTG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell- specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation. 

Sequence Annotation

 DOMAIN 32 109 RRM.  

Keyword

 Cell cycle; Complete proteome; Cytoplasm; Differentiation; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003730; F:mRNA 3'-UTR binding; IEA:Compara.
 GO:0003729; F:mRNA binding; IMP:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Compara.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Compara.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0010830; P:regulation of myotube differentiation; IDA:UniProtKB.
 GO:0043484; P:regulation of RNA splicing; IEA:Compara.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS