UniProt Accession

 SLMA_ECOLI; P0C093; P06969; Q2M7V5 

Genbank Protein ID

 X01714; V01578; V01498; L10328; U00096; AP009048 

Genbank Nucleotide ID

 CAA25860.1; CAA24898.1; AAA61994.1; AAC76665.2; BAE77651.1 

Protein Name

 Nucleoid occlusion factor SlmA 

Protein Synonyms/Alias

 Protein Ttk; Synthetically lethal with a defective Min system protein A 

Gene Name

 slmA 

Gene Synonyms/Alias

 ttk; yicB; b3641; JW5641 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
79	TRINLILKDEKDTTA	acetylation	[1]
82	NLILKDEKDTTARLR	acetylation	[1]
179	RFVRSEFKYRPTDDF	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. 

Sequence Annotation

 DOMAIN 10 70 HTH tetR-type.
 DNA_BIND 33 52 H-T-H motif (By similarity).  

Keyword

 3D-structure; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0043590; C:bacterial nucleoid; IDA:EcoCyc.
 GO:0005737; C:cytoplasm; IEA:HAMAP.
 GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
 GO:0000918; P:barrier septum site selection; IMP:EcoliWiki.
 GO:0010974; P:negative regulation of barrier septum assembly; IDA:EcoliWiki.
 GO:0032272; P:negative regulation of protein polymerization; IDA:EcoCyc.
 GO:0043547; P:positive regulation of GTPase activity; IDA:EcoliWiki. 

Interpro

 IPR023772; DNA-bd_HTH_TetR-type_CS.
 IPR009057; Homeodomain-like.
 IPR001647; HTH_TetR.
 IPR023769; NO_SlmA.
 IPR015893; Tet_transcr_reg_TetR-like_C.
 IPR011075; Tet_transcr_reg_TetR-rel_C. 

Pfam

 PF00440; TetR_N 

SMART

  

PROSITE

 PS01081; HTH_TETR_1
 PS50977; HTH_TETR_2 

PRINTS