CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007291
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-taxilin 
Protein Synonyms/Alias
  
Gene Name
 TXLNA 
Gene Synonyms/Alias
 TXLN 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
195KLAALCKKYAELLEEubiquitination[1]
240KAVLARSKLESLCREubiquitination[2]
256QRHNRSLKEEGVQRAubiquitination[1]
311ELAERLKKLIEQYELubiquitination[2]
325LREEHIDKVFKHKDLacetylation[3]
330IDKVFKHKDLQQQLVubiquitination[1]
403EFQNTLSKSSEVFTTubiquitination[4, 5, 6, 7]
427KKIKKLEKETTMYRSubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells. 
Sequence Annotation
 MOD_RES 515 515 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Exocytosis; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MKNQDKKNGA AKQSNPKSSP GQPEAGPEGA QERPSQAAPA VEAEGPGSSQ APRKPEGAQA 60
RTAQSGALRD VSEELSRQLE DILSTYCVDN NQGGPGEDGA QGEPAEPEDA EKSRTYVARN 120
GEPEPTPVVN GEKEPSKGDP NTEEIRQSDE VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN 180
TLSTPEEKLA ALCKKYAELL EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK 240
LESLCRELQR HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ 300
ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE AEERHQREKD 360
FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT LSKSSEVFTT FKQEMEKMTK 420
KIKKLEKETT MYRSRWESSN KALLEMAEEK TVRDKELEGL QVKIQRLEKL CRALQTERND 480
LNKRVQDLSA GGQGSLTDSG PERRPEGPGA QAPSSPRVTE APCYPGAPST EASGQTGPQE 540
PTSARA 546 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:LIFEdb.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005125; F:cytokine activity; NAS:UniProtKB.
 GO:0030372; F:high molecular weight B cell growth factor receptor binding; NAS:UniProtKB.
 GO:0008283; P:cell proliferation; NAS:UniProtKB.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW. 
Interpro
 IPR026183; Taxilin_fam. 
Pfam
 PF09728; Taxilin 
SMART
  
PROSITE
  
PRINTS