| Tag | Content |
|---|
| CPLM ID | CPLM-011418 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleolar complex protein 4 |
Protein Synonyms/Alias | U three protein 19; U3 small nucleolar RNA-associated protein 19; U3 snoRNA-associated protein 19 |
Gene Name | NOC4 |
Gene Synonyms/Alias | UTP19; YPR144C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 353 | NPDLMHVKYRARFFR | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein. |
Sequence Annotation | |
Keyword | Complete proteome; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 552 AA |
Protein Sequence | MVLLISEIKD IAKRLTAAGD RKQYNSIIKL INELVIPENV TQLEEDETEK NLRFLVMSLF 60
QIFRKLFSRG DLTLPSSKKS TLEKEQFVNW CRKVYEAFKT KLLAIISDIP FETSLGLDSL 120
DVYLQLAELE STHFASEKGA PFFPNKTFRK LIIALWSSNM GEIEDVKSSG ASENLIIVEF 180
TEKYYTKFAD IQYYFQSEFN QLLEDPAYQD LLLKNVGKWL ALVNHDKHCS SVDADLEIFV 240
PNPPQAIENE SKFKSNFEKN WLSLLNGQLS LQQYKSILLI LHKRIIPHFH TPTKLMDFLT 300
DSYNLQSSNK NAGVVPILAL NGLFELMKRF NLEYPNFYMK LYQIINPDLM HVKYRARFFR 360
LMDVFLSSTH LSAHLVASFI KKLARLTLES PPSAIVTVIP FIYNLIRKHP NCMIMLHNPA 420
FISNPFQTPD QVANLKTLKE NYVDPFDVHE SDPELTHALD SSLWELASLM EHYHPNVATL 480
AKIFAQPFKK LSYNMEDFLD WNYDSLLNAE SSRKLKTLPT LEFEAFTNVF DNEDGDSEAS 540
SQGNVYLPGV AW 552 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0030692; C:Noc4p-Nop14p complex; IPI:SGD. GO:0005730; C:nucleolus; IDA:SGD. GO:0032040; C:small-subunit processome; IDA:SGD. GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |