UniProt Accession

 CRBB2_HUMAN; P43320; Q9UCM8 

Genbank Protein ID

 L10035; U72404; U72400; U72401; U72402; U72403; CR456426; Z99916; BC069535 

Genbank Nucleotide ID

 AAA16864.1; AAB39700.1; AAB39700.1; AAB39700.1; AAB39700.1; AAB39700.1; CAG30312.1; CAB17043.1; AAH69535.1 

Protein Name

 Beta-crystallin B2 

Protein Synonyms/Alias

 Beta-B2 crystallin; Beta-crystallin Bp 

Gene Name

 CRYBB2 

Gene Synonyms/Alias

 CRYB2; CRYB2A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	DHQTQAGKPQSLNPK	methylation	[1]
42	NGPCPNLKETGVEKA	methylation	[2, 3]
68	GYEQANCKGEQFVFE	methylation	[2]
76	GEQFVFEKGEYPRWD	acetylation	[2]
120	ENPNFTGKKMEIIDD	methylation	[2]
121	NPNFTGKKMEIIDDD	acetylation	[2]
121	NPNFTGKKMEIIDDD	methylation	[3]

Reference

 [1] Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
 Wilmarth PA, Tanner S, Dasari S, Nagalla SR, Riviere MA, Bafna V, Pevzner PA, David LL.
 J Proteome Res. 2006 Oct;5(10):2554-66. [PMID: 17022627]
 [2] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738]
 [3] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Crystallins are the dominant structural components of the vertebrate eye lens. 

Sequence Annotation

 DOMAIN 17 56 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 57 101 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 107 148 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 149 191 Beta/gamma crystallin 'Greek key' 4.
 REGION 2 16 N-terminal arm.
 REGION 102 106 Connecting peptide.
 REGION 193 205 C-terminal arm.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Cataract; Complete proteome; Direct protein sequencing; Eye lens protein; Oxidation; Polymorphism; Reference proteome; Repeat; Sensory transduction; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; NAS:ProtInc.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 

Pfam

 PF00030; Crystall 

SMART

 SM00247; XTALbg 

PROSITE

 PS50915; CRYSTALLIN_BETA_GAMMA 

PRINTS

 PR01367; BGCRYSTALLIN.