| Tag | Content |
|---|
| CPLM ID | CPLM-004578 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclic AMP-dependent transcription factor ATF-7 |
Protein Synonyms/Alias | cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A |
Gene Name | ATF7 |
Gene Synonyms/Alias | ATFA |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 118 | STPDIKIKEEEPVEV | sumoylation | [1] |
|
Reference | [1] Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Hamard PJ, Boyer-Guittaut M, Camuzeaux B, Dujardin D, Hauss C, Oelgeschläger T, Vigneron M, Kedinger C, Chatton B. Nucleic Acids Res. 2007;35(4):1134-44. [ PMID: 17264123] |
Functional Description | Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. |
Sequence Annotation | DOMAIN 343 406 bZIP.
ZN_FING 7 31 C2H2-type.
REGION 1 296 Transactivation domain.
REGION 336 494 Essential for binding adenovirus 2 E1A.
REGION 345 365 Basic motif (By similarity).
REGION 371 399 Leucine-zipper (By similarity).
MOD_RES 51 51 Phosphothreonine; by MAPK11.
MOD_RES 53 53 Phosphothreonine.
MOD_RES 112 112 Phosphothreonine.
MOD_RES 424 424 Phosphoserine.
CROSSLNK 118 118 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Activator; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Host-virus interaction; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 494 AA |
Protein Sequence | MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN 60
CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA AAGPLDMSLP STPDIKIKEE 120
EPVEVDSSPP DSPASSPCSP PLKEKEVTPK PVLISTPTPT IVRPGSLPLH LGYDPLHPTL 180
PSPTSVITQA PPSNRQMGSP TGSLPLVMHL ANGQTMPVLP GPPVQMPSVI SLARPVSMVP 240
NIPGIPGPPV NSSGSISPSG HPIPSEAKMR LKATLTHQVS SINGGCGMVV GTASTMVTAR 300
PEQSQILIQH PDAPSPAQPQ VSPAQPTPST GGRRRRTVDE DPDERRQRFL ERNRAAASRC 360
RQKRKLWVSS LEKKAEELTS QNIQLSNEVT LLRNEVAQLK QLLLAHKDCP VTALQKKTQG 420
YLESPKESSE PTGSPAPVIQ HSSATAPSNG LSVRSAAEAV ATSVLTQMAS QRTELSMPIQ 480
SHVIMTPQSQ SAGR 494 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0034399; C:nuclear periphery; IDA:UniProtKB. GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. GO:0051019; F:mitogen-activated protein kinase binding; IDA:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc. GO:0008134; F:transcription factor binding; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |