UniProt Accession

 ACM1_YEAST; Q08981; D6W3A3 

Genbank Protein ID

 Z73623; AY558139; BK006949 

Genbank Nucleotide ID

 CAA98002.1; AAS56465.1; DAA11169.1 

Protein Name

 APC/C-CDH1 modulator 1 

Protein Synonyms/Alias

  

Gene Name

 ACM1 

Gene Synonyms/Alias

 YPL267W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
25	QKPRAVVKGNELRSP	ubiquitination	[1]
105	KENLSPAKICPYERA	ubiquitination	[1]
123	EGGRIALKDLSVDEF	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1. 

Sequence Annotation

 MOD_RES 48 48 Phosphoserine.
 MOD_RES 161 161 Phosphothreonine.
 MOD_RES 202 202 Phosphoserine.  

Keyword

 3D-structure; Cell cycle; Cell division; Complete proteome; Mitosis; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0055105; F:ubiquitin-protein ligase inhibitor activity; IDA:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; IDA:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

  

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