CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026459
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tripeptidyl peptidase I 
Protein Synonyms/Alias
 Tripeptidyl peptidase I, isoform CRA_d; Tripeptidyl-peptidase 1 
Gene Name
 Tpp1 
Gene Synonyms/Alias
 rCG_39632 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
373WSVSGRHKFRPSFPAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 563 AA 
Protein Sequence
MGLQARFLGL LALVIAGKCT HSPEPDQRWM LPPGWVSLGR VDPEEELSLT FALKQQNLDR 60
LSELVQAVSD PSSPRYGKYL TLEDVAELVQ PSPLTLCTVQ KWLLAAGARD CHSVTTQDFL 120
TCWLSVRQAE LLLPGAEFHR YVGGPAKTHI IRSPHPYQLP QALAPHVDFV AGLHRFPPLS 180
SPRQRPEPQG VGPVGLHLGV TPSVLRQRYN LTARDVGSGT TNNSQACAQF LEQYFHNSDL 240
TEFMRLFGSS FAHQASVARV VGKQGRGRAG IEASLDVEYL MSAGANISTW VYSSPGRHEA 300
QEPFLQWLLL LSNESSLPHV HTVSYGDDED SLSSVYIQRV NTEFMKAAAR GLTLLFASGD 360
TGAGCWSVSG RHKFRPSFPA SSPYVTTVGG TSFKNPFLVT NEVVDYISGG GFSNVFPQPS 420
YQEEAVAQFL KSSSHLPPSS YFNASGRAYP DVAALSDGYW VVSNMVPIPW VSGTSASTPV 480
FGGILSLINE HRLLNGRPPL GFLNPRLYQQ HGAGLFDVTH GCHESCLNEE VEGQGFCSGP 540
GWDPVTGWGT PNFPALLKTL LNP 563 
Gene Ontology
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0008240; F:tripeptidyl-peptidase activity; IEA:Compara.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0007040; P:lysosome organization; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0043171; P:peptide catabolic process; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR015366; Peptidase_S53_propep.
 IPR000209; Peptidase_S8/S53_dom.
 IPR009020; Prot_inh_propept. 
Pfam
 PF00082; Peptidase_S8
 PF09286; Pro-kuma_activ 
SMART
 SM00944; Pro-kuma_activ 
PROSITE
  
PRINTS