CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytosine-specific methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 DNMT1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58EFLQTEIKNQLCDLEubiquitination[1, 2]
70DLETKLRKEELSEEGubiquitination[2]
81SEEGYLAKVKSLLNKubiquitination[3]
83EGYLAKVKSLLNKDLubiquitination[2]
88KVKSLLNKDLSLENGubiquitination[2, 4]
134SPPKPLSKPRTPRRSubiquitination[4]
335TPKEPTEKKMARAKTacetylation[3]
347AKTVMNSKTHPPKCIubiquitination[3]
385PQMLTNEKLSIFDANubiquitination[1, 5, 6]
586PCMRDLIKLAGVTLGubiquitination[1, 2, 3, 4, 5, 6]
666CQQPECGKCKACKDMubiquitination[1, 2]
675KACKDMVKFGGSGRSubiquitination[2, 3]
739SWVGEAVKTDGKKSYubiquitination[2]
881ARFESPPKTQPTEDNubiquitination[2]
889TQPTEDNKFKFCVSCubiquitination[2]
928VLYYSATKNGILYRVubiquitination[2, 4]
961SPVKRPRKEPVDEDLubiquitination[2, 3, 5]
975LYPEHYRKYSDYIKGubiquitination[2]
981RKYSDYIKGSNLDAPubiquitination[1, 2, 3, 4, 5, 6, 7]
997PYRIGRIKEIFCPKKubiquitination[2, 3, 4, 7]
1020DIKIRVNKFYRPENTubiquitination[2]
1092FLEAYNAKSKSFEDPubiquitination[1, 2, 4, 5]
1094EAYNAKSKSFEDPPNubiquitination[2]
1135SEPEIEIKLPKLRTLubiquitination[2, 3]
1214RGQRLPQKGDVEMLCubiquitination[1, 2]
1275VRNFVSFKRSMVLKLubiquitination[1]
1323LAAAPGEKLPLFPEPubiquitination[1, 2, 3, 5]
1348LSVVVDDKKFVSNITubiquitination[7]
1349SVVVDDKKFVSNITRubiquitination[2]
1415ILRDHICKDMSALVAubiquitination[1, 2, 3, 7]
1486VEGGSSGKACDPAARubiquitination[3]
1538TNPEPMGKQGRVLHPubiquitination[1, 5, 6]
1575LFGNILDKHRQVGNAubiquitination[2, 4]
1589AVPPPLAKAIGLEIKubiquitination[2, 3, 5]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1619 AA 
Protein Sequence
MPARTAPARV PTLAVPAISL PDDVRRRLKD LERDSLTEKE CVKEKLNLLH EFLQTEIKNQ 60
LCDLETKLRK EELSEEGYLA KVKSLLNKDL SLENGAHAYN REVNGRLENG NQARSEARRV 120
GMADANSPPK PLSKPRTPRR SKSDGEAKPE PSPSPRITRK STRQTTITSH FAKGPAKRKP 180
QEESERAKSD ESIKEEDKDQ DEKRRRVTSR ERVARPLPAE EPERAKSGTR TEKEEERDEK 240
EEKRLRSQTK EPTPKQKLKE EPDREARAGV QADEDEDGDE KDEKKHRSQP KDLAAKRRPE 300
EKEPEKVNPQ ISDEKDEDEK EEKRRKTTPK EPTEKKMARA KTVMNSKTHP PKCIQCGQYL 360
DDPDLKYGQH PPDAVDEPQM LTNEKLSIFD ANESGFESYE ALPQHKLTCF SVYCKHGHLC 420
PIDTGLIEKN IELFFSGSAK PIYDDDPSLE GGVNGKNLGP INEWWITGFD GGEKALIGFS 480
TSFAEYILMD PSPEYAPIFG LMQEKIYISK IVVEFLQSNS DSTYEDLINK IETTVPPSGL 540
NLNRFTEDSL LRHAQFVVEQ VESYDEAGDS DEQPIFLTPC MRDLIKLAGV TLGQRRAQAR 600
RQTIRHSTRE KDRGPTKATT TKLVYQIFDT FFAEQIEKDD REDKENAFKR RRCGVCEVCQ 660
QPECGKCKAC KDMVKFGGSG RSKQACQERR CPNMAMKEAD DDEEVDDNIP EMPSPKKMHQ 720
GKKKKQNKNR ISWVGEAVKT DGKKSYYKKV CIDAETLEVG DCVSVIPDDS SKPLYLARVT 780
ALWEDSSNGQ MFHAHWFCAG TDTVLGATSD PLELFLVDEC EDMQLSYIHS KVKVIYKAPS 840
ENWAMEGGMD PESLLEGDDG KTYFYQLWYD QDYARFESPP KTQPTEDNKF KFCVSCARLA 900
EMRQKEIPRV LEQLEDLDSR VLYYSATKNG ILYRVGDGVY LPPEAFTFNI KLSSPVKRPR 960
KEPVDEDLYP EHYRKYSDYI KGSNLDAPEP YRIGRIKEIF CPKKSNGRPN ETDIKIRVNK 1020
FYRPENTHKS TPASYHADIN LLYWSDEEAV VDFKAVQGRC TVEYGEDLPE CVQVYSMGGP 1080
NRFYFLEAYN AKSKSFEDPP NHARSPGNKG KGKGKGKGKP KSQACEPSEP EIEIKLPKLR 1140
TLDVFSGCGG LSEGFHQAGI SDTLWAIEMW DPAAQAFRLN NPGSTVFTED CNILLKLVMA 1200
GETTNSRGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY SKFKNSLVVS FLSYCDYYRP 1260
RFFLLENVRN FVSFKRSMVL KLTLRCLVRM GYQCTFGVLQ AGQYGVAQTR RRAIILAAAP 1320
GEKLPLFPEP LHVFAPRACQ LSVVVDDKKF VSNITRLSSG PFRTITVRDT MSDLPEVRNG 1380
ASALEISYNG EPQSWFQRQL RGAQYQPILR DHICKDMSAL VAARMRHIPL APGSDWRDLP 1440
NIEVRLSDGT MARKLRYTHH DRKNGRSSSG ALRGVCSCVE GGSSGKACDP AARQFNTLIP 1500
WCLPHTGNRH NHWAGLYGRL EWDGFFSTTV TNPEPMGKQG RVLHPEQHRV VSVRECARSQ 1560
GFPDTYRLFG NILDKHRQVG NAVPPPLAKA IGLEIKLCML AKARESASAK IKEEEAAKD 1619 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:EC.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001025; BAH_dom.
 IPR018117; C5_DNA_meth_AS.
 IPR001525; C5_MeTfrase.
 IPR022702; Cytosine_MeTrfase1_RFD.
 IPR010506; DMAP1-bd.
 IPR017198; DNA_C5-MeTrfase_1_euk.
 IPR002857; Znf_CXXC. 
Pfam
 PF01426; BAH
 PF06464; DMAP_binding
 PF00145; DNA_methylase
 PF12047; DNMT1-RFD
 PF02008; zf-CXXC 
SMART
 SM00439; BAH 
PROSITE
 PS51038; BAH
 PS00094; C5_MTASE_1
 PS00095; C5_MTASE_2
 PS51058; ZF_CXXC 
PRINTS
 PR00105; C5METTRFRASE.