UniProt Accession

 CTSR4_HUMAN; Q7RTX7; A1A4W6; Q5VY71 

Genbank Protein ID

 AL355877; BC128138; BC128139; BN000273 

Genbank Nucleotide ID

 CAH71538.1; AAI28139.1; AAI28140.1; CAE30475.1 

Protein Name

 Cation channel sperm-associated protein 4 

Protein Synonyms/Alias

 CatSper4 

Gene Name

 CATSPER4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
466	SSSQILLKKHKSSH*	ubiquitination	[1, 2]
467	SSQILLKKHKSSH**	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. 

Sequence Annotation

  

Keyword

 Alternative splicing; Calcium; Calcium channel; Calcium transport; Cell membrane; Cell projection; Cilium; Complete proteome; Developmental protein; Differentiation; Flagellum; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 472 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0036128; C:CatSper complex; ISS:UniProtKB.
 GO:0005929; C:cilium; IEA:UniProtKB-KW.
 GO:0005227; F:calcium activated cation channel activity; IEA:Compara.
 GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
 GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0001539; P:ciliary or flagellar motility; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006814; P:sodium ion transport; IEA:Compara.
 GO:0030317; P:sperm motility; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR005821; Ion_trans_dom. 

Pfam

 PF00520; Ion_trans 

SMART

  

PROSITE

  

PRINTS