UniProt Accession

 HIS1_YEAST; P00498; D3DLV8 

Genbank Protein ID

 V01306; U18813; BK006939 

Genbank Nucleotide ID

 CAA24613.1; AAB64591.1; DAA07712.1 

Protein Name

 ATP phosphoribosyltransferase 

Protein Synonyms/Alias

 ATP-PRT; ATP-PRTase 

Gene Name

 HIS1 

Gene Synonyms/Alias

 YER055C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
17	RLLFAIPKKGRLYSK	acetylation	[1]
24	KKGRLYSKSVSILNG	acetylation	[1]
24	KKGRLYSKSVSILNG	ubiquitination	[2]
128	TIVTSFVKLAEKYFA	ubiquitination	[2]
132	SFVKLAEKYFADLEG	ubiquitination	[2]
242	DKLPELLKVTPGRRA	acetylation	[1]
280	GVVLDELKRLGASDI	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity). 

Sequence Annotation

  

Keyword

 Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Glycosyltransferase; Histidine biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003879; F:ATP phosphoribosyltransferase activity; IMP:SGD.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0000105; P:histidine biosynthetic process; IMP:SGD. 

Interpro

 IPR013820; ATP_PRibTrfase_cat.
 IPR018198; ATP_PRibTrfase_CS.
 IPR001348; ATP_PRibTrfase_HisG.
 IPR020621; ATP_PRibTrfase_HisG_long.
 IPR013115; HisG_C.
 IPR011322; N-reg_PII-like_a/b.
 IPR015867; N-reg_PII/ATP_PRibTrfase_C. 

Pfam

 PF01634; HisG
 PF08029; HisG_C 

SMART

  

PROSITE

 PS01316; ATP_P_PHORIBOSYLTR 

PRINTS