CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-adducin 
Protein Synonyms/Alias
 Erythrocyte adducin subunit alpha 
Gene Name
 ADD1 
Gene Synonyms/Alias
 ADDA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55DFNMMEQKKRVSMILubiquitination[1]
140SDSIAYDKGEKLLRCubiquitination[1]
348LVLLNPEKYKAKSRSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. 
Sequence Annotation
 REGION 717 734 Interaction with calmodulin (Potential).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 59 59 Phosphoserine; by PKA.
 MOD_RES 331 331 Phosphothreonine.
 MOD_RES 334 334 Phosphoserine.
 MOD_RES 355 355 Phosphoserine (By similarity).
 MOD_RES 358 358 Phosphoserine.
 MOD_RES 408 408 Phosphoserine; by PKA.
 MOD_RES 431 431 Phosphoserine.
 MOD_RES 436 436 Phosphoserine; by PKA.
 MOD_RES 445 445 Phosphothreonine; by ROCK2.
 MOD_RES 465 465 Phosphoserine.
 MOD_RES 480 480 Phosphothreonine; by ROCK2.
 MOD_RES 481 481 Phosphoserine; by PKA.
 MOD_RES 483 483 Phosphoserine (By similarity).
 MOD_RES 586 586 Phosphoserine.
 MOD_RES 614 614 Phosphothreonine (By similarity).
 MOD_RES 707 707 Phosphoserine.
 MOD_RES 710 710 Phosphoserine.
 MOD_RES 714 714 Phosphoserine.
 MOD_RES 716 716 Phosphoserine; by PKC.
 MOD_RES 726 726 Phosphoserine; by PKA and PKC.  
Keyword
 Acetylation; Actin-binding; Alternative splicing; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 737 AA 
Protein Sequence
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM 60
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS 120
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF 180
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI 240
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 300
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV 360
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS 420
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT 480
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT 540
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS 600
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK 660
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK 720
KFRTPSFLKK SKKKSDS 737 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008290; C:F-actin capping protein complex; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0051015; F:actin filament binding; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0030507; F:spectrin binding; IDA:BHF-UCL.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0051017; P:actin filament bundle assembly; IDA:BHF-UCL.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0051016; P:barbed-end actin filament capping; IDA:BHF-UCL.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0006884; P:cell volume homeostasis; IEA:Compara.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0071300; P:cellular response to retinoic acid; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0020027; P:hemoglobin metabolic process; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0045807; P:positive regulation of endocytosis; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IDA:BHF-UCL. 
Interpro
 IPR001303; Aldolase_II/adducin_N. 
Pfam
 PF00596; Aldolase_II 
SMART
 SM01007; Aldolase_II 
PROSITE
  
PRINTS