CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Smad nuclear interacting protein 1 
Protein Synonyms/Alias
  
Gene Name
 Snip1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
205IPRPAGNKNKEVPVKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). 
Sequence Annotation
 DOMAIN 272 335 FHA.
 MOD_RES 18 18 Phosphoserine (By similarity).
 MOD_RES 33 33 Phosphoserine (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).
 MOD_RES 386 386 Phosphoserine (By similarity).
 CROSSLNK 28 28 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Coiled coil; Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 389 AA 
Protein Sequence
MKAGKSERER SSRRRHRSGD ALATVVVKQE RLSPEPVAHR RPDAPAASPP PPAAESGSAG 60
HRGSRARGAS RSPAKKKSKS SGRRSKSPRT KRSRSPHYST VKVKQEREDH PRRGREDRQH 120
RELSEQEHRR ARNSERDRHR GHARQRRSSD ERPVSGQGRD RDSQILQAQE EERDFNNARR 180
REHRQQNESA GAEAQEVIPR PAGNKNKEVP VKEKPSFELS GALLEDTNTF RGVVIKYSEP 240
PEARIPKKRW RLYPFKNDEV LPVMYIHRQS AYLLGRHRRI ADIPIDHPSC SKQHAVFQYR 300
LVEYTRADGT VGRRVKPYII DLGSGNGTFL NNKRIEPQRY YELKEKDVLK FGFSSREYVL 360
LHESSDTSEL DRKEDEDEEE EEEMVSDSS 389 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; ISS:UniProtKB. 
Interpro
 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA 
SMART
 SM00240; FHA 
PROSITE
 PS50006; FHA_DOMAIN 
PRINTS