UniProt Accession

 RAB1A_HUMAN; P62820; P11476; Q6FIE7; Q96N61; Q9Y3T2 

Genbank Protein ID

 M28209; AL050268; BX571747; AK055927; AF498929; CR533479; CH471053; BC000905 

Genbank Nucleotide ID

 AAA60240.1; CAB43369.1; CAE11872.1; BAB71048.1; AAM21077.1; CAG38510.1; EAW99921.1; AAH00905.1 

Protein Name

 Ras-related protein Rab-1A 

Protein Synonyms/Alias

 YPT1-related protein 

Gene Name

 RAB1A 

Gene Synonyms/Alias

 RAB1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	YASENVNKLLVGNKC	ubiquitination	[1]
123	ATAGGAEKSNVKIQS	ubiquitination	[1]
127	GAEKSNVKIQSTPVK	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity. 

Sequence Annotation

 NP_BIND 18 26 GTP.
 NP_BIND 66 70 GTP (By similarity).
 NP_BIND 124 127 GTP.
 NP_BIND 154 156 GTP.
 MOTIF 40 48 Effector region (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 79 79 O-(2-cholinephosphoryl)serine; by
 MOD_RES 194 194 Phosphoserine; by CDK1 (Probable).
 LIPID 204 204 S-geranylgeranyl cysteine.
 LIPID 205 205 S-geranylgeranyl cysteine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; TAS:ProtInc. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.