UniProt Accession

 LAX1_HUMAN; Q8IWV1; B7Z744; J3KP69; Q6NSZ6; Q9NXB4 

Genbank Protein ID

 AY090784; AK000347; AK301421; AC114402; CH471067; BC069650; BC089408 

Genbank Nucleotide ID

 AAM09818.1; BAA91101.1; BAH13480.1; EAW91491.1; AAH69650.1; AAH89408.1 

Protein Name

 Lymphocyte transmembrane adapter 1 

Protein Synonyms/Alias

 Linker for activation of X cells; Membrane-associated adapter protein LAX 

Gene Name

 LAX1 

Gene Synonyms/Alias

 LAX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	PQTRQRAKNIYDILP	ubiquitination	[1, 2, 3]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 

Sequence Annotation

 MOD_RES 193 193 Phosphotyrosine (Probable).
 MOD_RES 268 268 Phosphotyrosine (Probable).
 MOD_RES 294 294 Phosphotyrosine (Probable).
 MOD_RES 345 345 Phosphotyrosine.
 MOD_RES 373 373 Phosphotyrosine.  

Keyword

 Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Immunity; Membrane; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0016021; C:integral to membrane; IDA:HGNC.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0019901; F:protein kinase binding; IDA:HGNC.
 GO:0042169; F:SH2 domain binding; IDA:HGNC.
 GO:0050851; P:antigen receptor-mediated signaling pathway; IEA:Compara.
 GO:0042113; P:B cell activation; IDA:HGNC.
 GO:0006955; P:immune response; IDA:HGNC.
 GO:0048305; P:immunoglobulin secretion; IEA:Compara.
 GO:0000188; P:inactivation of MAPK activity; IMP:HGNC.
 GO:0035556; P:intracellular signal transduction; IDA:HGNC.
 GO:0050868; P:negative regulation of T cell activation; IDA:HGNC. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS