CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017273
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon regulatory factor 2-binding protein-like 
Protein Synonyms/Alias
 Enhanced at puberty protein 1 
Gene Name
 Irf2bpl 
Gene Synonyms/Alias
 Eap1; Kiaa1865 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
79PPPPVGVKTVALSAKacetylation[1]
79PPPPVGVKTVALSAKubiquitination[2]
437RGLSSGFKYLEYEKKubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May contribute to the control of female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). 
Sequence Annotation
 ZN_FING 694 741 RING-type; degenerate.
 MOD_RES 195 195 Phosphoserine.
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 526 526 Phosphoserine.
 MOD_RES 636 636 Phosphoserine.
 MOD_RES 637 637 Phosphoserine.
 MOD_RES 638 638 Phosphoserine.
 MOD_RES 641 641 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 775 AA 
Protein Sequence
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV IETARQLKRA 60
HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAQQQQQ QQQQQQQQLN HVDGSTKPAV 120
LAAPSGLERY GLSAAAAAAA AAAAVEQRSR FEYPPPPVSL GSSSHAARLP NGLGGPNGFP 180
KPAPEEGPPE LNRQSPNSSS AATSVASRRG THSGLVTGLP NPGGGGGPQL TVPPNLLPQT 240
LLNGPASAAV LPPPHGLGGS RGPPTPAPPG APGGPACLGG PPGVSATVSS APSSTSSTVA 300
EVGVGAAGKR PGSVSSTDQE RELKEKQRNA EALAELSESL RNRAEEWANK PKMVRDTLLT 360
LAGCTPYEVR FKKDHSLLGR VFAFDAVSKP GMDYELKLFI EYPTGSGNVY SSASGVAKQM 420
YQDCMKDFGR GLSSGFKYLE YEKKHGSGDW RLLGDLLPEA VRFFKEGVPG ADMLPQPYLD 480
ASCPMLPTAL VSLSRAPSAP PGTGALPPAA PTGRGAASSL RKRKASPEPP DSAESALKLG 540
EEQQRQQWMA NQSEALKLTM SAGGFAAPGH SAGGPPPPPP PLGPHSNRTT PPESAPQNGP 600
SPMAALMSVA DTLGTAHSPK DGSSVHSTTA SARRNSSSPV SPASVPGQRR LASRNGDLNL 660
QVAPPPPSAH PGMDQVHPQN IPDSPMANSG PLCCTICHER LEDTHFVQCP SVPSHKFCFP 720
CSRESIKAQG ATGEVYCPSG EKCPLVGSNV PWAFMQGEIA TILAGDVKVK KERDP 775 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR022750; Interferon_reg_fac2-bd1_2_Znf. 
Pfam
 PF11261; IRF-2BP1_2 
SMART
  
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS