| Tag | Content |
|---|
| CPLM ID | CPLM-014303 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement factor I |
Protein Synonyms/Alias | C3B/C4B inactivator; Complement factor I heavy chain; Complement factor I light chain |
Gene Name | Cfi |
Gene Synonyms/Alias | If |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | DQKCLLQKYTHRSCN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. |
Sequence Annotation | DOMAIN 58 111 Kazal-like.
DOMAIN 117 217 SRCR.
DOMAIN 218 262 LDL-receptor class A 1.
DOMAIN 263 299 LDL-receptor class A 2.
DOMAIN 361 594 Peptidase S1.
ACT_SITE 401 401 Charge relay system (By similarity).
ACT_SITE 449 449 Charge relay system (By similarity).
ACT_SITE 545 545 Charge relay system (By similarity).
CARBOHYD 106 106 N-linked (GlcNAc...) (Potential).
CARBOHYD 116 116 N-linked (GlcNAc...).
CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
CARBOHYD 182 182 N-linked (GlcNAc...) (Potential).
CARBOHYD 267 267 N-linked (GlcNAc...) (Potential).
CARBOHYD 514 514 N-linked (GlcNAc...).
CARBOHYD 556 556 N-linked (GlcNAc...) (Potential).
DISULFID 36 260 By similarity.
DISULFID 46 57 By similarity.
DISULFID 51 62 By similarity.
DISULFID 64 96 By similarity.
DISULFID 70 89 By similarity.
DISULFID 78 109 By similarity.
DISULFID 144 186 By similarity.
DISULFID 157 219 By similarity.
DISULFID 191 201 By similarity.
DISULFID 234 252 By similarity.
DISULFID 264 276 By similarity.
DISULFID 271 289 By similarity.
DISULFID 283 298 By similarity.
DISULFID 348 473 Interchain (between heavy and light
DISULFID 386 402 By similarity.
DISULFID 394 464 By similarity.
DISULFID 487 551 By similarity.
DISULFID 515 530 By similarity.
DISULFID 541 570 By similarity. |
Keyword | Calcium; Cleavage on pair of basic residues; Complement pathway; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Immunity; Innate immunity; Metal-binding; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 603 AA |
Protein Sequence | MKLAHLSLFL LALHLSSSRS PSASDLPQEE LVDQKCLLQK YTHRSCNKVF CQPWQRCIEG 60
TCICKLPYQC PRAGTPVCAM NGRSYPTYCH QKSFECLHPE IKFSHNGTCA AEGKFNVSLI 120
YGRTKTEGLV QVKLVDQDER MFICKNSWSM AEANVACVDL GFPLGVRDIQ GSFNISGNLH 180
INDTECLHVH CRGVETSLAE CAFTKRRTEL SNGLAGVVCY KQDADFPTSL SFQCVNGKHI 240
PQEKACNGVN DCGDQSDELC CKGCRGNASL CKSGVCIPDQ YKCNGEVDCI TGEDESRCEE 300
DRQQNIPKGL ARSAQGEAEI ETEETEMLTP GMDNERKRIK SLLPKLSCGV KRNTHTRRKR 360
VIGGKPANVG DYPWQVAIKD GQRITCGGIY IGGCWILTAA HCVRPSRAHS YQVWTALLDW 420
LKPNSQLGIQ TVKRVIVHEK YNGATFQNDI ALIEMKMHTG KKECELPNSV PACVPWSPYL 480
FQPNDRCIIS GWGRGKDNQK VYSLRWGEVD LIGNCSQFYP DRYYEKEMQC AGTRDGSIDA 540
CKGDSGGPLV CEDINNVTYV WGIVSWGENC GKPEFPGVYT RVANYFDWIS YHVGRSLVSQ 600
HNV 603 |
Gene Ontology | GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005044; F:scavenger receptor activity; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |