CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019147
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulator of microtubule dynamics protein 1 
Protein Synonyms/Alias
 RMD-1; hRMD-1; Protein FAM82B 
Gene Name
 RMDN1 
Gene Synonyms/Alias
 FAM82B; CGI-90 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191IANAYIIKEHFEKAIacetylation[1]
230WYQRRIAKMLFATPPubiquitination[2, 3, 4, 5]
243PPSSTYEKALGYFHRubiquitination[2, 4, 5]
261VDPNFYSKNLLLLGKubiquitination[2, 3, 4, 5, 6]
268KNLLLLGKTYLKLHNubiquitination[3]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 REPEAT 168 204 TPR 1.
 REPEAT 222 258 TPR 2.  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MALAARLWRL LPFRRGAAPG SRLPAGTSGS RGHCGPCRFR GFEVMGNPGT FKRGLLLSAL 60
SYLGFETYQV ISQAAVVHAT AKVEEILEQA DYLYESGETE KLYQLLTQYK ESEDAELLWR 120
LARASRDVAQ LSRTSEEEKK LLVYEALEYA KRALEKNESS FASHKWYAIC LSDVGDYEGI 180
KAKIANAYII KEHFEKAIEL NPKDATSIHL MGIWCYTFAE MPWYQRRIAK MLFATPPSST 240
YEKALGYFHR AEQVDPNFYS KNLLLLGKTY LKLHNKKLAA FWLMKAKDYP AHTEEDKQIQ 300
TEAAQLLTSF SEKN 314 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. 
Interpro
 IPR011990; TPR-like_helical. 
Pfam
  
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS