| Tag | Content |
|---|
| CPLM ID | CPLM-012219 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rap guanine nucleotide exchange factor 1 |
Protein Synonyms/Alias | CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3G |
Gene Name | RAPGEF1 |
Gene Synonyms/Alias | GRF2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 200 | KAVLDGVKELVRLTI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. |
Sequence Annotation | DOMAIN 688 810 N-terminal Ras-GEF.
DOMAIN 840 1064 Ras-GEF.
MOTIF 281 292 SH3-binding.
MOTIF 451 462 SH3-binding.
MOTIF 538 549 SH3-binding.
MOTIF 606 617 SH3-binding.
MOD_RES 293 293 Phosphoserine.
MOD_RES 360 360 Phosphoserine.
MOD_RES 504 504 Phosphotyrosine; by HCK. |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism; Reference proteome; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1077 AA |
Protein Sequence | MDTDSQRSHL SSFTMKLMDK FHSPKIKRTP SKKGKPAEVS VKIPEKPVNK EATDRFLPEG 60
YPLPLDLEQQ AVEFMSTSAV ASRSQRQKNL SWLEEKEKEV VSALRYFKTI VDKMAIDKKV 120
LEMLPGSASK VLEAILPLVQ NDPRIQHSSA LSSCYSRVYQ SLANLIRWSD QVMLEGVNSE 180
DKEMVTTVKG VIKAVLDGVK ELVRLTIEKQ GRPSPTSPVK PSSPASKPDG PAELPLTDRE 240
VEILNKTTGM SQSTELLPDA TDEEVAPPKP PLPGIRVVDN SPPPALPPKK RQSAPSPTRV 300
AVVAPMSRAT SGSSLPVGIN RQDFDVDCYA QRRLSGGSHS YGGESPRLSP CSSIGKLSKS 360
DEQLSSLDRD SGQCSRNTSC ETLDHYDPDY EFLQQDLSNA DQIPQQTAWN LSPLPESLGE 420
SGSPFLGPPF QLPLGGHPQP DGPLAPGQQT DTPPALPEKK RRSAASQTAD GSGCRVSYER 480
HPSQYDNISG EDLQSTAPIP SVPYAPFAAI LPFQHGGSSA PVEFVGDFTA PESTGDPEKP 540
PPLPEKKNKH MLAYMQLLED YSEPQPSMFY QTPQNEHIYQ QKNKLLMEVY GFSDSFSGVD 600
SVQELAPPPA LPPKQRQLEP PAGKDGHPRD PSAVSGVPGK DSRDGSERAP KSPDALESAQ 660
SEEEVDELSL IDHNEIMSRL TLKQEGDDGP DVRGGSGDIL LVHATETDRK DLVLYCEAFL 720
TTYRTFISPE ELIKKLQYRY EKFSPFADTF KKRVSKNTFF VLVRVVDELC LVELTEEILK 780
LLMELVFRLV CNGELSLARV LRKNILDKVD QKKLLRCATS SQPLAARGVA ARPGTLHDFH 840
SHEIAEQLTL LDAELFYKIE IPEVLLWAKE QNEEKSPNLT QFTEHFNNMS YWVRSIIMLQ 900
EKAQDRERLL LKFIKIMKHL RKLNNFNSYL AILSALDSAP IRRLEWQKQT SEGLAEYCTL 960
IDSSSSFRAY RAALSEVEPP CIPYLGLILQ DLTFVHLGNP DYIDGKVNFS KRWQQFNILD 1020
SMRCFQQAHY DMRRNDDIIN FFNDFSDHLA EEALWELSLK IKPRNITRRK TDREEKT 1077 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005768; C:endosome; TAS:Reactome. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0000186; P:activation of MAPKK activity; TAS:Reactome. GO:0001568; P:blood vessel development; IEA:Compara. GO:0016337; P:cell-cell adhesion; IEA:Compara. GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara. GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |