UniProt Accession

 HUTI_MOUSE; Q9DBA8; Q7TPP5; Q811K3; Q8R230 

Genbank Protein ID

 AK005066; BC022626; BC043681; BC055025; BC118616; BC121826 

Genbank Nucleotide ID

 BAB23790.1; AAH22626.1; AAH43681.1; AAH55025.1; AAI18617.1; AAI21827.1 

Protein Name

 Probable imidazolonepropionase 

Protein Synonyms/Alias

 Amidohydrolase domain-containing protein 1 

Gene Name

 Amdhd1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	GPAAVIQKQFSGETF	acetylation	[1]
61	GPAAVIQKQFSGETF	ubiquitination	[2]
198	AHSVPKGKTAVEAAD	ubiquitination	[2]
235	NIDVFCEKGVFDLDT	ubiquitination	[2]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 METAL 87 87 Zinc or iron (By similarity).
 METAL 89 89 Zinc or iron (By similarity).
 METAL 260 260 Zinc or iron (By similarity).
 METAL 334 334 Zinc or iron (By similarity).
 BINDING 96 96 Substrate (By similarity).
 BINDING 109 109 Substrate (By similarity).
 BINDING 159 159 Substrate (By similarity).
 BINDING 192 192 Substrate (By similarity).
 BINDING 263 263 Substrate (By similarity).  

Keyword

 Complete proteome; Histidine metabolism; Hydrolase; Iron; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 426 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0050480; F:imidazolonepropionase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
 GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. 

Interpro

 IPR005920; HutI.
 IPR011059; Metal-dep_hydrolase_composite. 

Pfam

  

SMART

  

PROSITE

  

PRINTS